ReviewCureus2022
Congenital Syphilis Epidemiology, Prevention, and Management in the United States: A 2022 Update.
Review in Cureus, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- The Congenital Syphilis Surge: Clinician Lessons to Turn the Rising Tide.Advances in pediatrics · 2026Review
- Factors associated with preterm birth and low birth weight among syphilis-infected pregnant women.BMC infectious diseases · 2026Article
- State-of-the-Art Review: Congenital Syphilis in the Modern Era: Current Strategies and Future Directions.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026Review
- HIV and Syphilis Coinfection in Pregnancy and Adverse Birth Outcomes in Uganda.The Journal of infectious diseases · 2026Article
- Association Between Maternal Syphilis Infection and Stillbirth Among Women Delivering at Jinja and Hoima Regional Referral Hospitals: An Unmatched Case-Control Study.Obstetrics and gynecology international · 2026Article
- Clinical and trichoscopic features of early congenital syphilis: a single-center cross-sectional study.Frontiers in medicine · 2026Article
- Risk factors and diagnostic indicators for congenital syphilis: a Nationwide retrospective survey.Epidemiology and infection · 2025Article
- Characterization of substance use disorder during pregnancy in a syphilis population.Pregnancy (Hoboken, N.J.) · 2025Article
- Implementing a 24/7 Congenital Syphilis Hotline for California Clinicians: Results From a 13-Week Pilot Project.Sexually transmitted diseases · 2025Article
- Trends in Congenital Syphilis Incidence and Mortality in Brazil's Southeast Region: A Time-Series Analysis (2008-2022).Epidemiologia (Basel, Switzerland) · 2025Article
- Neonatal syphilis: clinical and laboratory assessments and postnatal treatments for infants born to infected mothers.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025Article
- Research Advances in Clinical Strategies and Preclinical Models for Syphilis Relapse.Infection and drug resistance · 2025Review
- Congenital syphilis related to primary health care and prenatal care coverage: a spatial analysis, Minas Gerais, 2020-2022.Epidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil · 2025Article
- Global, regional, and national burden and trends of syphilis among women of childbearing age from 1990 to 2021.Frontiers in public health · 2025Article
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- Article
- Global, regional, and national burden of syphilis, 1990-2021 and predictions by Bayesian age-period-cohort analysis: a systematic analysis for the global burden of disease study 2021.Frontiers in medicine · 2024Article
- Exposure toMicroorganisms · 2023Article
- Congenital Syphilis-An Illustrative Review.Children (Basel, Switzerland) · 2023Review
- Adverse pregnancy outcomes and associated risk factors among pregnant women with syphilis during 2013-2018 in Hunan, China.Frontiers in medicine · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Congenital syphilis (CS) has dramatically increased in the United States (US) in the past decade despite the widespread availability of penicillin. Once considered an infection on the verge of elimination, CS has re-emerged as a familiar neonatal pathogen in US hospitals. This rise in cases has prompted the evaluation of potential causes and updates in prevention and management guidelines. Following a structured narrative approach, we reviewed CS data reports, peer-reviewed research articles, and updated management guidelines from state health departments over the past two decades. Our main search criteria centered on the treatment and prevention of CS, with a focus on prenatal health disparities. We identified geographical regions reporting disproportionate rates of CS, examined state laws regarding maternal syphilis testing, and evaluated potential reasons for the recent rise in cases. This article examines the current epidemiology, screening, and management recommendations for perinatal and CS in the US. It also reviews pathogenesis and clinical features in perinatal and pediatric populations. Finally, it highlights the likely contributing factors to increased CS rates and identifies areas for future research. Dramatically rising CS cases in certain regions and racial groups reflect gaps in the prevention, timely diagnosis, treatment, and management of perinatal syphilis and CS. Healthcare providers attending to mothers and children should recognize the re-emergence of this pathogen and be familiar with new screening and management guidelines. Increased federal funding for targeted interventions and research that address vulnerable populations is critical to curbing the re-emergence of this infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.