Evidence map›Paper›PMID 36712571›Full record

ArticleBiological psychiatry global open science2023

A Prospective Evaluation of Infant Cerebellar-Cerebral Functional Connectivity in Relation to Behavioral Development in Autism Spectrum Disorder.

Zoë W Hawks, Alexandre Todorov, Natasha Marrus, Tomoyuki Nishino, Muhamed Talovic, Mary Beth Nebel, Jessica B Girault, Savannah Davis, Scott Marek, Benjamin A Seitzman and 23 more

Open access · goldAbstract read
In one paragraph

Article in Biological psychiatry global open science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Neural Correlates of Novelty-Evoked Distress in 4-Month-Old Infants: A Synthetic Cohort Study.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024
    Article
  8. Article
  9. Visual Autism.Children (Basel, Switzerland) · 2023
    Review
  10. Decoding microRNAs in autism spectrum disorder.Molecular therapy. Nucleic acids · 2022
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors at 11 institutions in 2 countries.

Zoë W HawksDepartment of Psychological and Brain Sciences, Washington University in St. Louis, St. Louis, Missouri.
Alexandre TodorovDepartment of Psychiatry, Washington University School of Medicine in St. Louis, St. Louis, Missouri.
Natasha MarrusDepartment of Psychiatry, Washington University School of Medicine in St. Louis, St. Louis, Missouri.
Tomoyuki NishinoDepartment of Psychiatry, Washington University School of Medicine in St. Louis, St. Louis, Missouri.
Muhamed TalovicDepartment of Psychiatry, Washington University School of Medicine in St. Louis, St. Louis, Missouri.
Mary Beth NebelDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Jessica B GiraultDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Savannah DavisDepartment of Psychiatry, Washington University School of Medicine in St. Louis, St. Louis, Missouri.
Scott MarekDepartment of Psychiatry, Washington University School of Medicine in St. Louis, St. Louis, Missouri.
Benjamin A SeitzmanDepartment of Neurology, Washington University School of Medicine in St. Louis, St. Louis, Missouri.
Adam T EggebrechtMallinckrodt Institute of Radiology, Washington University School of Medicine in St. Louis, St. Louis, Missouri.
Jed ElisonInstitute of Child Development, University of Minnesota, Minneapolis, Minnesota.
Stephen DagerDepartments of Radiology, University of Washington, Seattle, Washington.
Matthew W MosconiLife Span Institute and Clinical Child Psychology Program, University of Kansas, Lawrence, Kansas.
Lawrence TychsenDepartment of Ophthalmology and Visual Sciences, Washington University School of Medicine in St. Louis, St. Louis, Missouri.
Abraham Z SnyderDepartment of Neurology, Washington University School of Medicine in St. Louis, St. Louis, Missouri.
Kelly BotteronDepartment of Psychiatry, Washington University School of Medicine in St. Louis, St. Louis, Missouri.
Annette EstesSpeech and Hearing Sciences, University of Washington, Seattle, Washington.
Alan EvansMcConnell Brain Imaging Center, Montreal Neurological Institute, Montreal, Quebec, Canada.
Guido GerigDepartment of Computer Science and Engineering, Tandon School of Engineering, New York University, New York, New York.
Heather C HazlettDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Robert C McKinstryMallinckrodt Institute of Radiology, Washington University School of Medicine in St. Louis, St. Louis, Missouri.
Juhi PandeyCenter for Autism Research, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania.
Robert T SchultzCenter for Autism Research, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania.
Martin StynerDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Jason J WolffDepartment of Educational Psychology, University of Minnesota, Minneapolis, Minnesota.
Lonnie ZwaigenbaumDepartment of Psychiatry, University of Alberta, Edmonton, Alberta, Canada.
Lori MarksonDepartment of Psychological and Brain Sciences, Washington University in St. Louis, St. Louis, Missouri.
Steven E PetersenDepartment of Neurology, Washington University School of Medicine in St. Louis, St. Louis, Missouri.
John N ConstantinoDepartment of Psychiatry, Washington University School of Medicine in St. Louis, St. Louis, Missouri.
Desirée A WhiteDepartment of Psychological and Brain Sciences, Washington University in St. Louis, St. Louis, Missouri.
Joseph PivenDepartment of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
John R PruettDepartment of Psychiatry, Washington University School of Medicine in St. Louis, St. Louis, Missouri.
Washington University in St. Louis · USUniversity of North Carolina at Chapel Hill · USChildren's Hospital of Philadelphia · USMallinckrodt (United States) · USUniversity of Minnesota · USUniversity of Washington · USJohns Hopkins University · USMontreal Neurological Institute and Hospital · CANew York University · USUniversity of Alberta · CAUniversity of Kansas · US

Funding

WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Cellular and molecular mechanisms governing cortical surface area overgrowth in iPSC-derived neural cells from longitudinally characterized individuals with autismR01HD055741 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Joseph Piven · 2007 to 2026
$52.6M
MRI-Based Presymptomatic Prediction of ASD, and Early Infant to School-Age Brain-Behavior Trajectories, Mechanisms, and Related OutcomesR01MH118362 · NIMH · WASHINGTON UNIVERSITY · PI John R Pruett · 2019 to 2026
$16.3M
WUIDDRC Supplement-Supporting the health and well-being of children with intellectual and developmental disability during COVID-19 pandemicP50HD103525 · NICHD · WASHINGTON UNIVERSITY · PI JOSEPH D DOUGHERTY, Natasha Marrus · 2020 to 2026
$15.5M
Preclinical CoreP50HD103573 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GABRIEL S DICHTER · 2020 to 2026
$9.7M
proj 3 - NINDS INSTIUTIONAL CENTER CORE GRANTS TO SUPPORT NEUROSCIENCE RESEARP30NS048056 · NINDS · WASHINGTON UNIVERSITY · PI MINTUN, MARK A. · 2004 to 2014
$7.4M
Development and neural mechanisms of repetitive behavior and sensory responsivity in autismR01MH116961 · NIMH · UNIVERSITY OF MINNESOTA · PI WOLFF, JASON J · 2018 to 2022
$2.8M
NINDS CENTER CORE FOR BRAIN IMAGINGP30NS098577 · NINDS · WASHINGTON UNIVERSITY · PI HERSHEY, TAMARA G, MARCUS, DANIEL SCOTT · 2016 to 2019
$2.4M
fcMRI in Infants at High Risk for AutismR01MH093510 · NIMH · WASHINGTON UNIVERSITY · PI PRUETT, JOHN R · 2012 to 2016
$2.4M
HIGH PERFORMANCE BIOMEDICAL IMAGING COMPUTER RESOURCESS10RR022984 · NCRR · WASHINGTON UNIVERSITY · PI PRIOR, FRED WILLIAM · 2009 to 2009
$1.9M
Genetic Liability for Autism and Infant Brain and Behavioral DevelopmentK01MH122779 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GIRAULT, JESSICA BULLINS · 2020 to 2024
$919k
Visual-Motor Development in Infants at High Risk for AutismK01MH109766 · NIMH · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI NEBEL, MARY BETH · 2016 to 2020
$753k
NCATS NIH HHS UL1 TR002345NCRR NIH HHS S10 RR022984NICHD NIH HHS P50 HD103525NICHD NIH HHS P50 HD103573NICHD NIH HHS R01 HD055741NIH HHS S10 OD018091NIMH NIH HHS F31 MH120918NIMH NIH HHS K01 MH109766NIMH NIH HHS K01 MH122779NIMH NIH HHS K99 MH121518NIMH NIH HHS R01 MH093510NIMH NIH HHS R01 MH116961NIMH NIH HHS R01 MH118362NINDS NIH HHS P30 NS048056NINDS NIH HHS P30 NS098577
6 · The paper itself

Abstract

Background: Autism spectrum disorder (ASD) is a neurodevelopmental disorder diagnosed based on social impairment, restricted interests, and repetitive behaviors. Contemporary theories posit that cerebellar pathology contributes causally to ASD by disrupting error-based learning (EBL) during infancy. The present study represents the first test of this theory in a prospective infant sample, with potential implications for ASD detection. Methods: Data from the Infant Brain Imaging Study ( Results: Cerebellar-FPN and cerebellar-DMN connections did not demonstrate associations with ASD. Functional connectivity magnetic resonance imaging enrichment identified 6-month correlates of later ASD-associated behaviors in networks of a priori interest (FPN, DMN), as well as in cingulo-opercular (also implicated in error signaling) and medial visual networks. Post hoc tests did not suggest a role for cerebellar connections. Conclusions: We failed to identify cerebellar functional connectivity-based contributions to ASD. However, we observed prospective correlates of ASD-associated behaviors in networks that support EBL. Future studies may replicate and extend network-level positive results, and tests of the cerebellum may investigate brain-behavior associations at different developmental stages and/or using different neuroimaging modalities.

Indexed as

AutismCerebellumDevelopmentError-based learningFunctional connectivityInfancy

Identifiers

PMID36712571
PMCPMC9874081
OpenAlexW4200321044

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.