ReviewFrontiers in nutrition2022
Combination of marine bioactive compounds and extracts for the prevention and treatment of chronic diseases.
Review in Frontiers in nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- In Vitro Antiviral Effects of Green-Lipped Mussel Oil and Low-Molecular-Weight Fucoidan on HSV, RSV, and SARS-CoV-2 Pseudovirus.Biomedicines · 2026Article
- Enhancing cancer treatment with marine algae-derived bioactive chemicals: a review.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Anti-Cancer Activity ofMarine drugs · 2025Article
- Potential of Marine Biomolecules: Advances in Extraction and Applications of Proteins, Polysaccharides, and Antioxidant Compounds.Foods (Basel, Switzerland) · 2025Review
- Marine-Derived Compounds Combined with Nanoparticles: A Focus on the Biomedical and Pharmaceutical Sector.Marine drugs · 2025Review
- Advances in Leaf Plant Bioactive Compounds: Modulation of Chronic Inflammation Related to Obesity.International journal of molecular sciences · 2025Review
- Effects of Black Cumin Seed Extract on Pancreatic Islet β-Cell Proliferation and Hypoglycemic Activity in Streptozotocin-Induced Diabetic Rats.Antioxidants (Basel, Switzerland) · 2025Article
- Harnessing nutrients and natural products for sustainable drug development against aging.Frontiers in pharmacology · 2025Review
- Functional Breads with Encapsulated Vitamin C and Fish Oil: Nutritional, Technological, and Sensory Attributes.Antioxidants (Basel, Switzerland) · 2024Article
- Comparative Effects of Crude Extracts and Bioactive Compounds fromAnimals : an open access journal from MDPI · 2024Article
- Bioactive Compounds from Natural Sources: Discovery, Evaluation, and Applications.Molecules (Basel, Switzerland) · 2024Article
- Article
- Article
- Effects of Cinnamon (Nutrients · 2023Article
- Phytochemical Constituents, Antimicrobial Properties and Bioactivity of Marine Red Seaweed (Foods (Basel, Switzerland) · 2023Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: In recent years, marine-based functional foods and combination therapy are receiving greater recognition for their roles in healthy lifestyle applications and are being investigated as viable and effective strategies for disease treatment or prevention. Aim of the review: This review article presents and discusses the relevant scientific publications that have studied the synergistic and additive effects of natural marine bioactive compounds and extract combinations with anti-obesity, anti-inflammatory, antioxidant, and chemopreventive activities in the last two decades. The paper presents the mechanism of action and health benefits of developed combinations and discusses the limitation of the studies. Furthermore, it recommends alternatives and directions for future studies. Finally, it highlights the factors for developing novel combinations of marine bioactive compounds. Key scientific concepts of review: Combination of marine bioactive compounds or extracts affords synergistic or additive effects by multiple means, such as multi-target effects, enhancing the bioavailability, boosting the bioactivity, and neutralizing adverse effects of compounds in the mixture. For the development of marine-based combinations, there are key points for consideration and issues to address: knowledge of the mechanism of action of individual compounds and their combinations, optimum ratio and dosing of compounds, and experimental models must all be taken into account. Strategies to increase the number and diversity of marine combinations, and further development of marine-based functional foods, are available. However, only a small number of natural marine bioactive combinations have been assessed, and most research has been focused on fish oil and carotenoid synergy. Therefore, more research and resources should be spent on developing novel marine bioactive combinations as functional foods and nutraceuticals.
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