Evidence map›Paper›PMID 36712485›Full record

ArticleACS central science2023

Biocatalytic Cascades toward Iminosugar Scaffolds Reveal Promiscuous Activity of Shikimate Dehydrogenases.

Christopher R B Swanson, Grayson J Ford, Ashley P Mattey, Léa Gourbeyre, Sabine L Flitsch

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS central science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. BEST: Basic Embedding Search Tool Enhancing Discovery of Novel Enzyme.Interdisciplinary sciences, computational life sciences · 2026
    Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Christopher R B SwansonManchester Institute of Biotechnology, School of Chemistry, The University of Manchester, 131 Princess Street, M1 7DNManchester, United Kingdom.
Grayson J FordManchester Institute of Biotechnology, School of Chemistry, The University of Manchester, 131 Princess Street, M1 7DNManchester, United Kingdom.
Ashley P MatteyManchester Institute of Biotechnology, School of Chemistry, The University of Manchester, 131 Princess Street, M1 7DNManchester, United Kingdom.
Léa GourbeyreManchester Institute of Biotechnology, School of Chemistry, The University of Manchester, 131 Princess Street, M1 7DNManchester, United Kingdom.
Sabine L FlitschManchester Institute of Biotechnology, School of Chemistry, The University of Manchester, 131 Princess Street, M1 7DNManchester, United Kingdom.ORCID https://orcid.org/0000-0003-3974-646X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Iminosugar scaffolds are highly sought-after pharmaceutical targets, but their chemical synthesis is lengthy and can suffer from poor scalability and purification. Here we report protecting-group-free chemoenzymatic and biocatalytic cascades to synthesize iminosugars from sugar-derived aminopolyols in two steps. Using galactose oxidase variant F

Identifiers

PMID36712485
PMCPMC9881201

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.