Evidence map›Paper›PMID 36712378›Full record

ArticlePNAS nexus2022

The staphylococcal biofilm protein Aap mediates cell-cell adhesion through mechanically distinct homophilic and lectin interactions.

Can Wang, Constance Chantraine, Albertus Viljoen, Andrew B Herr, Paul D Fey, Alexander R Horswill, Marion Mathelié-Guinlet, Yves F Dufrêne

Open access · goldAbstract read
In one paragraph

Article in PNAS nexus, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 20 citations in OpenAlex.

  1. Journal of bacteriology · 2025
    Review
  2. UltrastrongScience advances · 2025
    Article
  3. Review
  4. Article
  5. bioRxiv : the preprint server for biology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Can WangLouvain Institute of Biomolecular Science and Technology, UCLouvain, Croix du Sud, 4-5, bte L7.07.07, B-1348 Louvain-la-Neuve, Belgium.
Constance ChantraineLouvain Institute of Biomolecular Science and Technology, UCLouvain, Croix du Sud, 4-5, bte L7.07.07, B-1348 Louvain-la-Neuve, Belgium.
Albertus ViljoenLouvain Institute of Biomolecular Science and Technology, UCLouvain, Croix du Sud, 4-5, bte L7.07.07, B-1348 Louvain-la-Neuve, Belgium.
Andrew B HerrDivisions of Immunobiology and Infectious Diseases, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Paul D FeyDepartment of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Alexander R HorswillDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Marion Mathelié-GuinletLouvain Institute of Biomolecular Science and Technology, UCLouvain, Croix du Sud, 4-5, bte L7.07.07, B-1348 Louvain-la-Neuve, Belgium.
Yves F DufrêneLouvain Institute of Biomolecular Science and Technology, UCLouvain, Croix du Sud, 4-5, bte L7.07.07, B-1348 Louvain-la-Neuve, Belgium.
UCLouvain · BECincinnati Children's Hospital Medical Center · USUniversity of Colorado Denver · USUniversity of Nebraska Medical Center · US

Funding

Mechanisms of staphylococcal skin colonizationR01AI162964 · NIAID · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI PAUL D FEY, ANDREW B HERR · 2022 to 2026
$2.4M
Mechanisms of staphylococcal skin colonizationR56AI162964 · NIAID · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI FEY, PAUL D, HERR, ANDREW B · 2021 to 2021
$651k
NIAID NIH HHS R01 AI162964NIAID NIH HHS R56 AI162964
6 · The paper itself

Abstract

The accumulation phase of staphylococcal biofilms relies on both the production of an extracellular polysaccharide matrix and the expression of bacterial surface proteins. A prototypical example of such adhesive proteins is the long multidomain protein Aap (accumulation-associated protein) from

Indexed as

Aaphomophilic interactionintercellular adhesionlectin bindingmechanical strength

Identifiers

PMID36712378
PMCPMC9802226
OpenAlexW4311159281

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.