Evidence map›Paper›PMID 36712347›Full record

ArticlePNAS nexus2022

Sequence patterns and signatures: Computational and experimental discovery of amyloid-forming peptides.

Xingqing Xiao, Alicia S Robang, Sudeep Sarma, Justin V Le, Michael E Helmicki, Matthew J Lambert, Ricardo Guerrero-Ferreira, Johana Arboleda-Echavarria, Anant K Paravastu, Carol K Hall

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PNAS nexus, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
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  4. Review
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  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xingqing XiaoDepartment of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695, USA.ORCID https://orcid.org/0000-0003-3462-3049
Alicia S RobangDepartment of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Sudeep SarmaDepartment of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695, USA.ORCID https://orcid.org/0000-0002-4642-7689
Justin V LeDepartment of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Michael E HelmickiDepartment of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Matthew J LambertDepartment of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Ricardo Guerrero-FerreiraRobert P. Apkarian Integrated Electron Microscopy Core, Emory University School of Medicine, Atlanta, GA 30322, USA.
Johana Arboleda-EchavarriaRobert P. Apkarian Integrated Electron Microscopy Core, Emory University School of Medicine, Atlanta, GA 30322, USA.
Anant K ParavastuDepartment of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.ORCID https://orcid.org/0000-0001-7183-1942
Carol K HallDepartment of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695, USA.ORCID https://orcid.org/0000-0002-7425-587X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Screening amino acid sequence space via experiments to discover peptides that self-assemble into amyloid fibrils is challenging. We have developed a computational

Indexed as

amyloid-forming peptidesdiscontinuous molecular dynamicsfourier-transform infrared spectroscopypeptide assembly designtransmission electron microscopy

Identifiers

PMID36712347
PMCPMC9802472

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.