Evidence map›Paper›PMID 36712344›Full record

ArticlePNAS nexus2022

Human threat learning is associated with gut microbiota composition.

Javiera P Oyarzun, Thomas M Kuntz, Yoann Stussi, Olivia T Karaman, Sophia Vranos, Bridget L Callaghan, Curtis Huttenhower, Joseph E LeDoux, Elizabeth A Phelps

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PNAS nexus, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Javiera P OyarzunDepartment of Psychology, Harvard University, Cambridge, MA 02138, USA.ORCID https://orcid.org/0000-0002-6486-0689
Thomas M KuntzDepartment of Biostatistics, Microbiome Analysis Core, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Yoann StussiDepartment of Psychology, Harvard University, Cambridge, MA 02138, USA.
Olivia T KaramanDepartment of Psychology, Harvard University, Cambridge, MA 02138, USA.
Sophia VranosDepartment of Psychology, Harvard University, Cambridge, MA 02138, USA.
Bridget L CallaghanDepartment of Psychology, UCLA, Los Angeles, CA 90095, USA.
Curtis HuttenhowerDepartment of Biostatistics, Microbiome Analysis Core, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.ORCID https://orcid.org/0000-0002-1110-0096
Joseph E LeDouxCenter for Neural Science and Department of Psychology, New York University, New York NY, 10003, USA.ORCID https://orcid.org/0000-0001-8518-132X
Elizabeth A PhelpsDepartment of Psychology, Harvard University, Cambridge, MA 02138, USA.

Funding

NRSA Training CoreTL1TR001447 · NCATS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MICOLI, KEITH J. · 2015 to 2025
$5.9M
NCATS NIH HHS TL1 TR001447
6 · The paper itself

Abstract

The ability to learn about threat and safety is critical for survival. Studies in rodent models have shown that the gut microbiota can modulate such behaviors. In humans, evidence showing an association with threat or extinction learning is lacking. Here, we tested whether individual variability in threat and extinction learning was related to gut microbiota composition in healthy adults. We found that threat, but not extinction learning, varies with individuals' microbiome composition. Our results provide evidence that the gut microbiota is associated with excitatory threat learning across species.

Indexed as

anxietygut microbiotahumanslearningthreat conditioning

Identifiers

PMID36712344
PMCPMC9802442

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.