Evidence map›Paper›PMID 36712142›Full record

ArticleJournal of clinical case reports2019

Steroid-Refractory Autoimmune Myocarditis after Pembrolizumab Therapy: Failure of Equine Anti-Thymocyte Globulin to Prevent Heart Failure.

N V Baclig, C Ngo, A C Yeh, S H Chung, A Cheng, J Grim, S A Graf, K C Yang

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Journal of clinical case reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact, top 62% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

N V BacligDepartment of Medicine, University of Washington, USA.
C NgoDivision of Cardiology, Department of Medicine, University of Washington, USA.
A C YehDivision of Hematology, Division of Medical Oncology, Department of Medicine, University of Washington, USA.
S H ChungDepartment of Pharmacology, Veterans Affairs Puget Sound Health Care System, USA.
A ChengDivision of Cardiology, Department of Medicine, University of Washington, USA.
J GrimDivision of Medical Oncology, Department of Medicine, University of Washington, USA.
S A GrafDivision of Medical Oncology, Department of Medicine, University of Washington, USA.
K C YangDivision of Cardiology, Department of Medicine, University of Washington, USA.
University of Washington · US

Funding

Intramural VA VA999999
6 · The paper itself

Abstract

While immune checkpoint inhibitors (ICIs) are improving outcomes for many cancers, they can have severe adverse effects. Though cardiac immune-related adverse effects (irAEs) are rare, they have considerable morbidity and mortality. Prior case studies have demonstrated successful treatment of ICI induced autoimmune myocarditis with a variety of immunosuppressive regimens. This case describes steroid-refractory autoimmune myocarditis after treatment with pembrolizumab. Treatment with equine anti-thymocyte globulin, a regimen previously documented to reverse ICI induced autoimmune myocarditis, temporarily improved clinical status and cardiac biomarkers, however eventually failed to prevent progression to heart failure and cardiovascular death. This case highlights the importance of early stress-dose steroids, identifies troponin as a potential marker of treatment response, and underscores the value of collaboration between oncology and cardiology for optimal management.

Indexed as

Anti-thymocyte globulinImmune checkpoint inhibitorImmune myocarditisImmune related adverse effects (irAE)ImmunotherapyPembrolizumab

Identifiers

PMID36712142
PMCPMC9881190
OpenAlexW4318542415

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.