Evidence map›Paper›PMID 36712134›Full record

ArticlebioRxiv : the preprint server for biology2023

Non-catalytic role of phosphoinositide 3-kinase in mesenchymal cell migration through non-canonical induction of p85β/AP-2-mediated endocytosis.

Hideaki T Matsubayashi, Jack Mountain, Tony Yao, Amy F Peterson, Abhijit Deb Roy, Takanari Inoue

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Hideaki T MatsubayashiDepartment of Cell Biology, School of Medicine, Johns Hopkins University.
Jack MountainDepartment of Cell Biology, School of Medicine, Johns Hopkins University.
Tony YaoDepartment of Cell Biology, School of Medicine, Johns Hopkins University.
Amy F PetersonDepartment of Cell Biology, School of Medicine, Johns Hopkins University.
Abhijit Deb RoyDepartment of Cell Biology, School of Medicine, Johns Hopkins University.
Takanari InoueDepartment of Cell Biology, School of Medicine, Johns Hopkins University.
Johns Hopkins University · US

Funding

BIOCHEMISTRY, CELLULAR AND MOLECULAR BIOLOGY PROGRAMT32GM007445 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI GREEN, RACHEL · 1985 to 2021
$24.1M
Feedback and Crosstalk in Eukaryotic ChemotaxisR01GM123130 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI INOUE, TAKANARI · 2018 to 2021
$1.5M
ActuAtor, a molecular tool for generating force in living cellsR01GM136858 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI INOUE, TAKANARI · 2020 to 2022
$983k
NIGMS NIH HHS R01 GM123130NIGMS NIH HHS R01 GM136858NIGMS NIH HHS T32 GM007445
6 · The paper itself

Abstract

Class IA phosphoinositide 3-kinase (PI3K) galvanizes fundamental cellular processes such as migration, proliferation, and differentiation. To enable multifaceted roles, the catalytic subunit p110 utilizes a multidomain, regulatory subunit p85 through its inter SH2 domain (iSH2). In cell migration, their product PI(3,4,5)P

Identifiers

PMID36712134
PMCPMC9881872
OpenAlexW4313525939

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.