Evidence map›Paper›PMID 36712115›Full record

ArticlebioRxiv : the preprint server for biology2023

Divergent Proteome Reactivity Influences Arm-Selective Activation of Pharmacological Endoplasmic Reticulum Proteostasis Regulators.

Gabriel M Kline, Ryan J Paxman, Chung-Yon Lin, Nicole Madrazo, Julia M Grandjean, Kyunga Lee, Karina Nugroho, Evan T Powers, R Luke Wiseman, Jeffery W Kelly

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Gabriel M KlineDepartment of Chemistry, The Scripps Research Institute, La Jolla, CA.
Ryan J PaxmanDepartment of Chemistry, The Scripps Research Institute, La Jolla, CA.
Chung-Yon LinDepartment of Chemistry, The Scripps Research Institute, La Jolla, CA.
Nicole MadrazoDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA.
Julia M GrandjeanDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA.
Kyunga LeeDepartment of Chemistry, The Scripps Research Institute, La Jolla, CA.
Karina NugrohoDepartment of Chemistry, The Scripps Research Institute, La Jolla, CA.
Evan T PowersDepartment of Chemistry, The Scripps Research Institute, La Jolla, CA.
R Luke WisemanDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, CA.
Jeffery W KellyDepartment of Chemistry, The Scripps Research Institute, La Jolla, CA.
Scripps Research Institute · US

Funding

Discovering small molecules activators of stress responsive signalingR01AG046495 · NIA · SCRIPPS RESEARCH INSTITUTE, THE · PI JEFFERY W KELLY, Rockland Luke Wiseman · 2013 to 2026
$6.0M
Discovering Small Molecule Activators of Stress-Responsive SignalingRF1AG046495 · NIA · SCRIPPS RESEARCH INSTITUTE, THE · PI KELLY, JEFFERY W, WISEMAN, ROCKLAND LUKE · 2023 to 2025
$2.8M
NIA NIH HHS R01 AG046495NIA NIH HHS RF1 AG046495
6 · The paper itself

Abstract

Pharmacological activation of the activating transcription factor 6 (ATF6) arm of the Unfolded Protein Response (UPR) has proven useful for ameliorating proteostasis deficiencies in a variety of etiologically diverse diseases. Previous high-throughput screening efforts identified the small molecule AA147 as a potent and selective ATF6 activating compound that operates through a mechanism involving metabolic activation of its 2-amino-

Identifiers

PMID36712115
PMCPMC9882204
OpenAlexW4317207583

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.