Evidence map›Paper›PMID 36712092›Full record

ArticleResearch square2023

Examining the Latent Structure and Correlates of Sensory Reactivity in Autism: A Multi-site Integrative Data Analysis by the Autism Sensory Research Consortium.

Zachary J Williams, Roseann Schaaf, Karla K Ausderau, Grace T Baranek, D Jonah Barrett, Carissa J Cascio, Rachel L Dumont, Ekomobong E Eyoh, Michelle D Failla, Jacob I Feldman and 23 more

Open access · greenAbstract readPreprint
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 6 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

33 authors at 17 institutions in 2 countries.

Zachary J WilliamsVanderbilt University School of Medicine.
Roseann SchaafThomas Jefferson University.
Karla K AusderauUniversity of Wisconsin-Madison.
Grace T BaranekUniversity of Southern California.
D Jonah BarrettVanderbilt University.
Carissa J CascioVanderbilt University Medical Center.
Rachel L DumontThomas Jefferson University.
Ekomobong E EyohUniversity of Minnesota.
Michelle D FaillaThe Ohio State University.
Jacob I FeldmanVanderbilt University Medical Center.
Jennifer H Foss-FeigIcahn School of Medicine at Mount Sinai.
Heather L GreenChildren's Hospital of Philadelphia.
Shulamite A GreenUniversity of California, Los Angeles.
Jason L HeKing's College London.
Elizabeth A Kaplan-KahnSyracuse University.
Bahar Keçeli-KaysılıVanderbilt University Medical Center.
Keren MacLennanUniversity of Reading.
Zoe MaillouxThomas Jefferson University.
Elysa J MarcoCortica Healthcare.
Lisa E MashBaylor College of Medicine.
Elizabeth P McKernanSyracuse University.
Sophie MolholmAlbert Einstein College of Medicine.
Stewart H MostofskyKennedy Krieger Institute.
Nicolaas A J PutsKing's College London.
Caroline E RobertsonDartmouth College.
Natalie RussoSyracuse University.
Nicole SheaSyracuse University.
John SiderisUniversity of Southern California.
James S SutcliffeVanderbilt University.
Teresa TavassoliUniversity of Reading.
Mark T WallaceVanderbilt University.
Ericka L WodkaKennedy Krieger Institute.
Tiffany G WoynaroskiVanderbilt University Medical Center.
Syracuse University · USVanderbilt University · USVanderbilt University Medical Center · USThomas Jefferson University · USKennedy Krieger Institute · USKing's College London · GBUniversity of Reading · GBUniversity of Southern California · USAlbert Einstein College of Medicine · USBaylor College of Medicine · USChildren's Hospital of Philadelphia · USDartmouth College · USIcahn School of Medicine at Mount Sinai · USThe Ohio State University · USUniversity of California, Los Angeles · USUniversity of Minnesota System · USUniversity of Wisconsin–Madison · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007347 · NIGMS · VANDERBILT UNIVERSITY · PI WILLIAMS, CHRISTOPHER S. · 1985 to 2023
$26.3M
Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at VanderbiltP50HD103537 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Jeffrey L Neul · 2020 to 2026
$10.3M
TRD 4: Platforms for multi-modal and multi-scale imaging dataP41EB031771 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI Peter CM Van Zijl · 2021 to 2026
$9.9M
Translational Neuroscience CoreU54HD079123 · NICHD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI FATEMI, S. ALI · 2014 to 2019
$7.9M
Research Project: Sensory and Multisensory Contributions to AutismU54HD083211 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI NEUL, JEFFREY L · 2015 to 2019
$7.1M
SUPPORT FOR THE ROSE F KENNEDY IDDRC P50P50HD105352 · NICHD · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI SOPHIE MOLHOLM, Steven Upshaw Walkley · 2021 to 2026
$7.0M
Sensorimotor integration governing facial expression production in autism.R01MH102272 · NIMH · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CASCIO, CARISSA J · 2014 to 2023
$4.3M
Unusual Sensory Experiences in Young Children w/AutismR01HD042168 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BARANEK, GRACE T · 2003 to 2012
$4.1M
Sensory Project in Infant/Toddler Siblings of Children with Autism (Project SPIS)R01DC020186 · NIDCD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Tiffany Woynaroski · 2022 to 2026
$3.2M
Sensory Integration Therapy in Autism: Mechanisms and EffectivenessR01HD082814 · NICHD · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI MOLHOLM, SOPHIE, SCHAAF, ROSEANN C · 2015 to 2019
$3.2M
The neurophysiology of sensory processing and multisensory integration in ASDR01MH101536 · NIMH · SYRACUSE UNIVERSITY · PI RUSSO, NATALIE · 2013 to 2017
$2.1M
Mechanisms underlying sensory over-responsivity in ASD and early adversityK08MH112871 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GREEN, SHULAMITE ABRA · 2017 to 2020
$798k
NIBIB NIH HHS P41 EB031771NICHD NIH HHS P50 HD103537NICHD NIH HHS P50 HD105352NICHD NIH HHS R01 HD042168NICHD NIH HHS R01 HD082814NICHD NIH HHS R21 HD100869NICHD NIH HHS U54 HD079123NICHD NIH HHS U54 HD083211NIDCD NIH HHS F30 DC019510NIDCD NIH HHS R01 DC020186NIGMS NIH HHS T32 GM007347NIMH NIH HHS K01 MH090232NIMH NIH HHS K08 MH112871NIMH NIH HHS K23 MH083890NIMH NIH HHS R00 MH107719NIMH NIH HHS R01 MH101536NIMH NIH HHS R01 MH102272NIMH NIH HHS R21 MH101321NIMH NIH HHS R21 MH109158
6 · The paper itself

Abstract

Background Differences in responding to sensory stimuli, including sensory hyperreactivity (HYPER), hyporeactivity (HYPO), and sensory seeking (SEEK) have been observed in autistic individuals across sensory modalities, but few studies have examined the structure of these "supra-modal" traits in the autistic population. Methods Leveraging a combined sample of 3,868 autistic youth drawn from 12 distinct data sources (ages 3-18 years and representing the full range of cognitive ability), the current study used modern psychometric and meta-analytic techniques to interrogate the latent structure and correlates of caregiver-reported HYPER, HYPO, and SEEK within and across sensory modalities. Bifactor statistical indices were used to both evaluate the strength of a "general response pattern" factor for each supra-modal construct and determine the added value of "modality-specific response pattern" scores (e.g., Visual HYPER). Bayesian random-effects integrative data analysis models were used to examine the clinical and demographic correlates of all interpretable HYPER, HYPO and SEEK (sub)constructs. Results All modality-specific HYPER subconstructs could be reliably and validly measured, whereas certain modality-specific HYPO and SEEK subconstructs were psychometrically inadequate when measured using existing items. Bifactor analyses unambiguously supported the validity of a supra-modal HYPER construct (ω

Identifiers

PMID36712092
PMCPMC9882639
OpenAlexW4315488022

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.