Evidence map›Paper›PMID 36712088›Full record

ArticleResearch square2023

Gut microbiota and diet matrix modulate the effects of the flavonoid quercetin on atherosclerosis.

Kazuyuki Kasahara, Robert L Kerby, Tzu-Wen L Cross, Jessica Everhart, Colin Kay, Bradley W Bolling, Fredrik Bäckhed, Federico E Rey

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 9 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Kazuyuki KasaharaDepartment of Bacteriology, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0000-0003-3303-7216
Robert L KerbyDepartment of Bacteriology, University of Wisconsin-Madison, Madison, WI, USA.
Tzu-Wen L CrossDepartment of Bacteriology, University of Wisconsin-Madison, Madison, WI, USA.
Jessica EverhartPlants for Human Health Institute, North Carolina State University, Kannapolis, NC, USA.
Colin KayPlants for Human Health Institute, North Carolina State University, Kannapolis, NC, USA.
Bradley W BollingDepartment of Food Science, University of Wisconsin-Madison, Madison, WI, USA.
Fredrik BäckhedWallenberg Laboratory, Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden.
Federico E ReyDepartment of Bacteriology, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0000-0002-0239-7780
University of Wisconsin–Madison · USNorth Carolina State University · USUniversity of Gothenburg · SE

Funding

Training Program in Translational Cardiovascular Science (TPTCS)T32HL007936 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Lee Lochbaum Eckhardt, Gail A Robertson · 2001 to 2026
$11.6M
Establishing mechanistic links between the gut microbiome and atherosclerosisR01HL148577 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI LUSIS, ALDONS JAKE, REY, FEDERICO E · 2020 to 2023
$2.6M
Gut microbiota and metabolite interactions in atherosclerosisR01HL144651 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LUSIS, ALDONS JAKE, REY, FEDERICO E · 2019 to 2022
$2.6M
NHLBI NIH HHS R01 HL144651NHLBI NIH HHS R01 HL148577NHLBI NIH HHS T32 HL007936
6 · The paper itself

Abstract

Gut bacterial metabolism of dietary flavonoids results in the production of a variety of phenolic acids, whose contributions to health remain poorly understood. Here, we show that supplementation with the commonly consumed flavonoid quercetin impacted gut microbiome composition and resulted in a significant reduction in atherosclerosis burden in conventionally-raised (ConvR)

Identifiers

PMID36712088
PMCPMC9882667
OpenAlexW4315433576

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.