Evidence map›Paper›PMID 36712072›Full record

ArticlebioRxiv : the preprint server for biology2023

The BR-body proteome contains a complex network of protein-protein and protein-RNA interactions.

V Nandana, I W Rathnayaka-Mudiyanselage, N S Muthunayak, A Hatami, C B Mousseau, L A Ortiz-Rodríguez, J Vaishnav, M Collins, A Gega, K S Mallikaarachchi and 7 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 1 country.

V NandanaWayne State University, Department of Biological Sciences, Detroit, MI.
I W Rathnayaka-MudiyanselageWayne State University, Department of Biological Sciences, Detroit, MI.
N S MuthunayakWayne State University, Department of Biological Sciences, Detroit, MI.
A HatamiWayne State University, Department of Chemical Engineering and Materials Science, Detroit, MI.
C B MousseauUniversity of Notre Dame, Department of Chemistry, Notre Dame, IN.
L A Ortiz-RodríguezUniversity of Michigan, Department of Chemistry, Ann Arbor, MI.
J VaishnavWayne State University, Department of Chemical Engineering and Materials Science, Detroit, MI.
M CollinsUniversity of Pittsburgh, Department of Chemistry, Pittsburgh, PA.
A GegaWayne State University, Department of Biological Sciences, Detroit, MI.
K S MallikaarachchiWayne State University, Department of Biological Sciences, Detroit, MI.
H YassineWayne State University, Department of Biological Sciences, Detroit, MI.
A GhoshWayne State University, Department of Biological Sciences, Detroit, MI.
J S BiteenUniversity of Michigan, Department of Chemistry, Ann Arbor, MI.
Y ZhuWayne State University, Department of Chemical Engineering and Materials Science, Detroit, MI.
M M ChampionUniversity of Notre Dame, Department of Chemistry, Notre Dame, IN.
W S ChildersUniversity of Pittsburgh, Department of Chemistry, Pittsburgh, PA.
J M SchraderWayne State University, Department of Biological Sciences, Detroit, MI.
Wayne State University · USUniversity of Michigan · USUniversity of Notre Dame · USUniversity of Pittsburgh · US

Funding

Mechanisms of Non-Shine-Dalgarno Translation InitiationR35GM124733 · NIGMS · WAYNE STATE UNIVERSITY · PI Jared Michael Schrader · 2017 to 2026
$3.6M
Physicochemical properties driving membraneless organelle assembly in bacteriaR01GM143182 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BITEEN, JULIE, MEYER, ANNE SARA · 2021 to 2024
$2.4M
Systematic Discovery and Analysis of Small Proteins and Small ORFs in MycobacteriaR01GM139277 · NIGMS · WADSWORTH CENTER · PI DERBYSHIRE, KEITH M, GRAY, TODD · 2020 to 2023
$2.2M
Biomolecular condensates as organizers of mRNA decay in bacteriaR01GM136863 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI William Seth Childers · 2020 to 2026
$1.9M
Mapping the Interactions and Dynamics that Organize Bacteria CellsR01GM144731 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BITEEN, JULIE · 2022 to 2025
$1.2M
NIGMS NIH HHS R01 GM136863NIGMS NIH HHS R01 GM139277NIGMS NIH HHS R01 GM143182NIGMS NIH HHS R01 GM144731NIGMS NIH HHS R35 GM124733
6 · The paper itself

Abstract

Bacterial RNP bodies (BR-bodies) are non-membrane-bound structures that facilitate mRNA decay by concentrating mRNA substrates with RNase E and the associated RNA degradosome machinery. However, the full complement of proteins enriched in BR-bodies has not been defined. Here we define the protein components of BR-bodies through enrichment of the bodies followed by mass spectrometry-based proteomic analysis. We found 111 BR-body enriched proteins, including several RNA binding proteins, many of which are also recruited directly to

Identifiers

PMID36712072
PMCPMC9882336
OpenAlexW4317373649

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.