Evidence map›Paper›PMID 36712060›Full record

ArticlebioRxiv : the preprint server for biology2023

Novel genetically encoded tools for imaging or silencing neuropeptide release from presynaptic terminals

Dong-Il Kim, Sekun Park, Mao Ye, Jane Y Chen, Jinho Jhang, Avery C Hunker, Larry S Zweifel, Richard D Palmiter, Sung Han

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Dong-Il KimPeptide Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Sekun ParkHoward Hughes Medical Institute, Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Mao YePeptide Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Jane Y ChenHoward Hughes Medical Institute, Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Jinho JhangPeptide Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Avery C HunkerDepartment of Pharmacology, University of Washington, Seattle, WA 98195, USA.
Larry S ZweifelDepartment of Pharmacology, University of Washington, Seattle, WA 98195, USA.
Richard D PalmiterHoward Hughes Medical Institute, Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
Sung HanPeptide Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA.
Salk Institute for Biological Studies · USHoward Hughes Medical Institute · USUniversity of Washington · US

Funding

Contribution of the Parabrachial CGRP-Expressing Neurons to the Pathophysiology of Panic DisorderR01MH116203 · NIMH · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI HAN, SUNG · 2018 to 2022
$3.0M
Monitoring presynaptic release of neuropeptides in awake behaving animalsRF1NS128680 · NINDS · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI HAN, SUNG · 2022 to 2022
$2.0M
NIMH NIH HHS R01 MH116203NINDS NIH HHS RF1 NS128680
6 · The paper itself

Abstract

Neurons produce and release neuropeptides to communicate with one another. Despite their profound impact on critical brain functions, circuit-based mechanisms of peptidergic transmission are poorly understood, primarily due to the lack of tools for monitoring and manipulating neuropeptide release

Identifiers

PMID36712060
PMCPMC9882317
OpenAlexW4317581831

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.