Evidence map›Paper›PMID 36712046›Full record

ArticlebioRxiv : the preprint server for biology2023

The myocardium utilizes Pdgfra-PI3K signaling to steer towards the midline during heart tube formation.

Rabina Shrestha, Tess McCann, Harini Saravanan, Jaret Lieberth, Prashanna Koirala, Joshua Bloomekatz

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Rabina ShresthaDepartment of Biology, University of Mississippi, University, MS 38677.
Tess McCannDepartment of Biology, University of Mississippi, University, MS 38677.
Harini SaravananDepartment of Biology, University of Mississippi, University, MS 38677.
Jaret LieberthDepartment of Biology, University of Mississippi, University, MS 38677.
Prashanna KoiralaDepartment of Biology, University of Mississippi, University, MS 38677.
Joshua BloomekatzDepartment of Biology, University of Mississippi, University, MS 38677.
University of Mississippi · US

Funding

Investigating collective myocardial cell movement during heart tube formationR15HD108782 · NICHD · UNIVERSITY OF MISSISSIPPI · PI BLOOMEKATZ, JOSHUA ELI · 2022 to 2022
$412k
Laser spectroscopic instrumentation for isotopic sensing of biogenic Nitric OxideR21GM103460 · NIGMS · PRINCETON UNIVERSITY · PI WYSOCKI, GERARD · 2012 to 2012
$190k
NICHD NIH HHS R15 HD108782NIGMS NIH HHS R21 GM103460
6 · The paper itself

Abstract

Coordinated cell movement is a fundamental process in organ formation. During heart development, bilateral myocardial precursors collectively move towards the midline (cardiac fusion) to form the primitive heart tube. Along with extrinsic influences such as the adjacent anterior endoderm which are known to be required for cardiac fusion, we previously showed that the platelet-derived growth factor receptor alpha (Pdgfra) is also required. However, an intrinsic mechanism that regulates myocardial movement remains to be elucidated. Here, we uncover an essential intrinsic role in the myocardium for the phosphoinositide 3-kinase (PI3K) intracellular signaling pathway in directing myocardial movement towards the midline.

Identifiers

PMID36712046
PMCPMC9881939
OpenAlexW4313456643

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.