ArticlebioRxiv : the preprint server for biology2024
Interactive computational and experimental approaches improve the sensitivity of periplasmic binding protein-based nicotine biosensors for measurements in biofluids.
Nandan Haloi, Shan Huang, Aaron L Nichols, Eve J Fine, Nicholas J Friesenhahn, Christopher B Marotta, Dennis A Dougherty, Erik Lindahl, Rebecca J Howard, Stephen L Mayo and 1 more
Open access · greenAbstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 4 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
11 authors at 3 institutions in 2 countries.
Nandan HaloiDepartment of Applied Physics, Science for Life Laboratory, KTH Royal Institute of Technology, 10044 Stockholm, Sweden.ORCID 0000-0003-3542-333X Shan HuangDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena CA 91125 USA.ORCID 0000-0002-4436-3327 Aaron L NicholsDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena CA 91125 USA.ORCID 0000-0001-9341-0049 Eve J FineDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena CA 91125 USA.
Nicholas J FriesenhahnDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena CA 91125 USA.
Christopher B MarottaDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena CA 91125 USA.
Dennis A DoughertyDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena CA 91125 USA.
Erik LindahlDepartment of Applied Physics, Science for Life Laboratory, KTH Royal Institute of Technology, 10044 Stockholm, Sweden.ORCID 0000-0002-2734-2794 Rebecca J HowardDepartment of Biochemistry and Biophysics, Science for Life Laboratory, Stockholm University, 10691 Stockholm, Sweden.ORCID 0000-0003-2049-3378 Stephen L MayoDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena CA 91125 USA.
Henry A LesterDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena CA 91125 USA.ORCID 0000-0002-5470-5255 California Institute of Technology · USStockholm University · SEScience for Life Laboratory · SE
Funding
Fluorescent biosensors for subcellular pharmacokineticsR01GM123582 · NIGMS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI LESTER, HENRY A. · 2016 to 2021
$3.8MOpioids inside OrganellesR21DA049140 · NIDA · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI LESTER, HENRY A. · 2019 to 2020
$452kNIDA NIH HHS R21 DA049140NIGMS NIH HHS R01 GM123582
6 · The paper itselfAbstract
We developed fluorescent protein sensors for nicotine with improved sensitivity. For iNicSnFR12 at pH 7.4, the proportionality constant for
Identifiers
PMID36712031
PMCPMC9882114
OpenAlexW4317497796
What OpenQuestion holds
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