Evidence map›Paper›PMID 36712013›Full record

ArticlebioRxiv : the preprint server for biology2023

A cathepsin C-like protease post-translationally modifies

L Brock Thornton, Melanie Key, Chiara Micchelli, Andrew J Stasic, Samuel Kwain, Katherine Floyd, Silvia N J Moreno, Brian N Dominy, Daniel C Whitehead, Zhicheng Dou

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

L Brock ThorntonDepartment of Biological Sciences, Clemson University, Clemson, South Carolina, United States of America.
Melanie KeyDepartment of Biological Sciences, Clemson University, Clemson, South Carolina, United States of America.
Chiara MicchelliDepartment of Biological Sciences, Clemson University, Clemson, South Carolina, United States of America.
Andrew J StasicCenter for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, United States of America.
Samuel KwainDepartment of Chemistry, Clemson University, Clemson, South Carolina, United States of America.
Katherine FloydDepartment of Biological Sciences, Clemson University, Clemson, South Carolina, United States of America.
Silvia N J MorenoCenter for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, United States of America.
Brian N DominyDepartment of Chemistry, Clemson University, Clemson, South Carolina, United States of America.
Daniel C WhiteheadEukaryotic Pathogens Innovation Center, Clemson University, Clemson, South Carolina, United States of America.
Zhicheng DouDepartment of Biological Sciences, Clemson University, Clemson, South Carolina, United States of America.
Clemson University · USUniversity of Georgia · US

Funding

Regulation of Cryptosporidium DevelopmentP20GM146584 · NIGMS · CLEMSON UNIVERSITY · PI JAMES Culvin MORRIS · 2022 to 2026
$13.5M
Training in Tropical and Emerging Global Diseases - SupplementT32AI060546 · NIAID · UNIVERSITY OF GEORGIA (UGA) · PI Silvia N Moreno, Vasant Muralidharan · 2004 to 2026
$5.1M
The Toxoplasma apicoplast and calcium signalingR01AI128356 · NIAID · UNIVERSITY OF GEORGIA · PI MORENO, SILVIA N · 2017 to 2021
$2.0M
Regulation of the physiology and function of the digestive vacuole in Toxoplasma gondiiR01AI143707 · NIAID · CLEMSON UNIVERSITY · PI DOU, ZHICHENG · 2020 to 2024
$1.8M
The plant-like vacuole of Toxoplasma gondiiR01AI096836 · NIAID · UNIVERSITY OF GEORGIA · PI MORENO, SILVIA N · 2012 to 2016
$1.8M
NIAID NIH HHS R01 AI096836NIAID NIH HHS R01 AI128356NIAID NIH HHS R01 AI143707NIAID NIH HHS T32 AI060546NIGMS NIH HHS P20 GM146584
6 · The paper itself

Abstract

Microbial pathogens use proteases for their infections, such as digestion of proteins for nutrients and activation of their virulence factors. As an obligate intracellular parasite, IMPORTANCE:

Identifiers

PMID36712013
PMCPMC9882377
OpenAlexW4317714083

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.