Evidence map›Paper›PMID 36711958›Full record

ArticlebioRxiv : the preprint server for biology2023

Plasticity in the functional properties of NMDA receptors improves network stability during severe energy stress.

Nikolaus Bueschke, Lara Amaral-Silva, Min Hu, Alvaro Alvarez, Joseph M Santin

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Nikolaus BueschkeUniversity of Missouri, Columbia, MO 65201.
Lara Amaral-SilvaUniversity of Missouri, Columbia, MO 65201.
Min HuUniversity of North Carolina-Greensboro, Greensboro, NC 27402.
Alvaro AlvarezUniversity of North Carolina-Greensboro, Greensboro, NC 27402.
Joseph M SantinUniversity of Missouri, Columbia, MO 65201.
University of Missouri · USUniversity of North Carolina at Greensboro · US

Funding

Homeostatic plasticity mechanisms regulate behavior in vivoR01NS114514 · NINDS · UNIVERSITY OF NORTH CAROLINA GREENSBORO · PI Joseph M Santin · 2021 to 2026
$1.5M
Acquiring resistance to anoxia in neural circuit functionR15NS112920 · NINDS · UNIVERSITY OF NORTH CAROLINA GREENSBORO · PI OSENA, AYALEW LIGABA · 2020 to 2020
$355k
NINDS NIH HHS R01 NS114514NINDS NIH HHS R15 NS112920
6 · The paper itself

Abstract

Brain energy stress leads to neuronal hyperexcitability followed by a rapid loss of function and cell death. In contrast, the frog brainstem switches into a state of extreme metabolic resilience that allows them to maintain motor function during hypoxia as they emerge from hibernation. NMDA receptors (NMDARs) are Ca

Identifiers

PMID36711958
PMCPMC9882286
OpenAlexW4317585458

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.