Evidence map›Paper›PMID 36711901›Full record

ArticlebioRxiv : the preprint server for biology2023

Hypersensitivity to distractors in Fragile X syndrome from loss of modulation of cortical VIP interneurons.

Noorhan Rahmatullah, Lauren M Schmitt, Lisa De Stefano, Sam Post, Jessica Robledo, Gunvant R Chaudhari, Ernest Pedapati, Craig A Erickson, Carlos Portera-Cailliau, Anubhuti Goel

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Noorhan RahmatullahNeuroscience Graduate Program, UC Riverside, CA.
Lauren M SchmittDepartment of Psychiatry, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, OH.
Lisa De StefanoDepartment of Psychiatry, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, OH.
Sam PostDepartment of Psychology, UC Riverside, CA.
Jessica RobledoDepartment of Psychology, UC Riverside, CA.
Gunvant R ChaudhariDepartment of Neurology, David Geffen School of Medicine at UCLA, CA.
Ernest PedapatiDepartment of Psychiatry, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, OH.
Craig A EricksonDepartment of Psychiatry, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, OH.
Carlos Portera-CailliauDepartment of Neurology, David Geffen School of Medicine at UCLA, CA.
Anubhuti GoelNeuroscience Graduate Program, UC Riverside, CA.
Cincinnati Children's Hospital Medical Center · USUniversity of California, Riverside · USUniversity of California, Los Angeles · US

Funding

Imaging the origin of dendritic spine abnormalities in fragile X miceR01HD054453 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Carlos Portera-Cailliau · 2007 to 2026
$6.5M
Circuit Disruptions Underlying Atypical Sensory Processing in Fragile X SyndromeR01NS117597 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ERICKSON, CRAIG, PORTERA-CAILLIAU, CARLOS · 2020 to 2024
$2.3M
NICHD NIH HHS R01 HD054453NINDS NIH HHS R01 NS117597
6 · The paper itself

Abstract

Attention deficit is one of the most prominent and disabling symptoms in Fragile X Syndrome (FXS). Hypersensitivity to sensory stimuli contributes to attention difficulties by overwhelming and/or distracting affected individuals, which disrupts activities of daily living at home and learning at school. We find that auditory or visual distractors selectively impair visual discrimination performance in both humans and mice with FXS, but not their typically developing controls. Vasoactive intestinal polypeptide (VIP) neurons were significantly modulated by incorrect responses in the post-stimulus period during early distractor trials in WT mice, consistent with their known role as 'error' signals. Strikingly, however, VIP cells from

Indexed as

attention-deficit disorderautism spectrum disorderscalcium imagingFmr1 knockoutinhibitionlayer 2/3two-photonVIPvisual cortex

Identifiers

PMID36711901
PMCPMC9881942
OpenAlexW4313548997

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.