Evidence map›Paper›PMID 36711890›Full record

ArticlebioRxiv : the preprint server for biology2023

Notch signaling regulates immunosuppressive tumor-associated macrophage function in pancreatic cancer.

Wei Yan, Nina G Steele, Samantha B Kemp, Rosa E Menjivar, Wenting Du, Eileen S Carpenter, Katelyn L Donahue, Kristee L Brown, Valerie Irizarry-Negron, Sion Yang and 4 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 6 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Wei YanDepartment of Surgery, University of Michigan, Ann Arbor, MI 48109, USA.
Nina G SteeleDepartment of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Samantha B KempMolecular and Cellular Pathology Graduate Program, University of Michigan, Ann Arbor, MI 48109, USA.
Rosa E MenjivarProgram in Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Wenting DuDepartment of Surgery, University of Michigan, Ann Arbor, MI 48109, USA.
Eileen S CarpenterDepartment of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor Ml 48109, USA.
Katelyn L DonahueCancer Biology Program, University of Michigan, Ann Arbor, MI 48109, USA.
Kristee L BrownDepartment of Surgery, University of Michigan, Ann Arbor, MI 48109, USA.
Valerie Irizarry-NegronDepartment of Surgery, University of Michigan, Ann Arbor, MI 48109, USA.
Sion YangCollege of Literature, Science, and the Arts, University of Michigan, Ann Arbor, MI 48109, USA.
William R BurnsDepartment of Surgery, University of Michigan, Ann Arbor, MI 48109, USA.
Yaqing ZhangDepartment of Surgery, University of Michigan, Ann Arbor, MI 48109, USA.
Marina Pasca di MaglianoDepartment of Surgery, University of Michigan, Ann Arbor, MI 48109, USA.
Filip BednarDepartment of Surgery, University of Michigan, Ann Arbor, MI 48109, USA.
University of Michigan · US

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Alexey I Nesvizhskii · 1988 to 2026
$178.2M
CELLULAR AND MOLECULAR BIOLOGY AT MICHIGANT32GM007315 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PUTHENVEEDU, MANOJKUMAR A · 1985 to 2021
$12.8M
Training Program in Tumor MicroenvironmentT32CA009676 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Maria G Castro, Analisa Virginia DiFeo · 1992 to 2026
$7.3M
TRAINING PROGRAM IN ORGANOGENESIST32HD007505 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PASCA DI MAGLIANO, MARINA, SPENCE, JASON · 1997 to 2021
$6.9M
Dissecting the role of Notch signaling in the pancreatic cancer microenvironment.R01CA271510 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Filip Bednar, Marina Pasca Di Magliano · 2022 to 2026
$2.6M
Interrupting Cellular Crosstalk in the Immunosuppressive Microenvironment of Pancreas CancerU01CA224145 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CRAWFORD, HOWARD C., PASCA DI MAGLIANO, MARINA · 2017 to 2021
$2.6M
Mechanisms of myeloid cell driven pancreatic plasticity and carcinogenesisR01CA268426 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Timothy Louis Frankel, Marina Pasca Di Magliano · 2023 to 2026
$2.5M
Training Program in Translational ResearchT32GM113900 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LIEBERMAN, ANDREW P, NIKOLOVSKA-COLESKA, ZANETA · 2016 to 2020
$991k
Establishment and regulation of the immune suppressive microenvironment in pancreatic cancerR01CA264843 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PASCA DI MAGLIANO, MARINA · 2022 to 2022
$492k
Targeting the Immunosuppressive Tumor Microenvironment in Pancreatic CancerR50CA232985 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ZHANG, YAQING · 2018 to 2022
$331k
Regulation and role of fibroblast-derived interleukin-33 in the pancreatic tumor microenvironmentF31CA265085 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DONAHUE, KATELYN LOIS · 2022 to 2024
$123k
Myeloid cell driven immune suppression in pancreatic cancerF31CA257533 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MENJIVAR, ROSA ELENA · 2021 to 2021
$37k
NCI NIH HHS F31 CA247076NCI NIH HHS F31 CA257533NCI NIH HHS F31 CA265085NCI NIH HHS P30 CA046592NCI NIH HHS R01 CA264843NCI NIH HHS R01 CA268426NCI NIH HHS R01 CA271510NCI NIH HHS R50 CA232985NCI NIH HHS T32 CA009676NCI NIH HHS U01 CA224145NICHD NIH HHS T32 HD007505NIGMS NIH HHS T32 GM007315NIGMS NIH HHS T32 GM113900
6 · The paper itself

Abstract

Pancreatic ductal adenocarcinoma (PDA) continues to have a dismal prognosis. The poor survival of patients with PDA has been attributed to a high rate of early metastasis and low efficacy of current therapies, which partly result from its complex immunosuppressive tumor microenvironment. Previous studies from our group and others have shown that tumor-associated macrophages (TAMs) are instrumental in maintaining immunosuppression in PDA. Here, we explored the role of Notch signaling, a key regulator of immune response, within the PDA microenvironment. We identified Notch pathway components in multiple immune cell types within human and mouse pancreatic cancer. TAMs, the most abundant immune cell population in the tumor microenvironment, express high levels of Notch receptors with cognate ligands such as

Indexed as

macrophagemicroenvironmentNotch signalingpancreatic cancerγ-secretase inhibitor

Identifiers

PMID36711890
PMCPMC9882066
OpenAlexW4315853549

What OpenQuestion holds

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LicenceCC BY-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.