Evidence map›Paper›PMID 36711875›Full record

ArticleResearch square2023

Oleoylethanolamide facilitates PPARa and TFEB signaling and attenuates Ab pathology in a mouse model of Alzheimer's disease.

Michele Comerota, Manasee Gedam, Wen Xiong, Feng Jin, Lisheng Deng, Meng Wang, Jin Wang, Hui Zheng

Open access · greenAbstract readPreprint
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Michele ComerotaBaylor College of Medicine.
Manasee GedamBaylor College of Medicine.
Wen XiongBaylor College of Medicine.
Feng JinBaylor College of Medicine.
Lisheng DengBaylor College of Medicine.
Meng WangJanelia.ORCID 0000-0002-5898-6007
Jin WangBaylor College of Medicine.ORCID 0000-0003-3625-7919
Hui ZhengBaylor College of Medicine.ORCID 0000-0002-5427-3798
Baylor College of Medicine · US

Funding

Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Michael M Ittmann · 2007 to 2026
$73.9M
TMEM106b as a lysosomal adaptor to influence brain aging and tau pathogenesisP01AG066606 · NIA · BAYLOR COLLEGE OF MEDICINE · PI ZHENG, HUI · 2021 to 2025
$13.5M
Targeting a lipid-mediated pro-longevity pathway as Alzheimer's therapyRF1AG062257 · NIA · BAYLOR COLLEGE OF MEDICINE · PI WANG, JIN, WANG, MENG CARLA · 2018 to 2020
$4.0M
Knockin mouse models of Alzheimer's DiseaseRF1AG020670 · NIA · BAYLOR COLLEGE OF MEDICINE · PI ZHENG, HUI · 2022 to 2022
$2.3M
ROLE OF TFEB IN TAUOPATHYRF1NS093652 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI ZHENG, HUI · 2021 to 2021
$1.5M
NCI NIH HHS P30 CA125123NIA NIH HHS P01 AG066606NIA NIH HHS RF1 AG020670NIA NIH HHS RF1 AG062257NINDS NIH HHS RF1 NS093652
6 · The paper itself

Abstract

Emerging evidence implicates impaired microglia function and dysregulation of lipid metabolism in Alzheimer's disease (AD). Oleoylethanolamide (OEA), an endogenous lipid and PPARα agonist, has been shown to promote longevity in

Identifiers

PMID36711875
PMCPMC9882642
OpenAlexW4317604192

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.