ArticlebioRxiv : the preprint server for biology2024
High-parameter phenotypic characterization reveals a subset of human Th17 cells that preferentially produce IL17 against
Paul Ogongo, Anthony Tran, Florence Marzan, David Gingrich, Melissa Krone, Francesca Aweeka, Cecilia S Lindestam Arlehamn, Jeffrey N Martin, Steven G Deeks, Peter W Hunt and 1 more
Open access · greenAbstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 1 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
11 authors at 2 institutions in 2 countries.
Anthony TranDivision of Experimental Medicine, University of California, San Francisco, CA, USA.
Florence MarzanDrug Research Unit, Department of Clinical Pharmacy, School of Pharmacy, University of California, San Francisco, CA, USA.
David GingrichDrug Research Unit, Department of Clinical Pharmacy, School of Pharmacy, University of California, San Francisco, CA, USA.
Melissa KroneDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.
Francesca AweekaDrug Research Unit, Department of Clinical Pharmacy, School of Pharmacy, University of California, San Francisco, CA, USA.
Cecilia S Lindestam ArlehamnCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.ORCID 0000-0001-7302-8002 Jeffrey N MartinDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.ORCID 0000-0002-9773-3256 Steven G DeeksDivision of HIV, Infectious Diseases, and Global Medicine, University of California, San Francisco, CA, USA.ORCID 0000-0001-6371-747X Peter W HuntDivision of Experimental Medicine, University of California, San Francisco, CA, USA.
Joel D ErnstDivision of Experimental Medicine, University of California, San Francisco, CA, USA.
University of California, San Francisco · USLa Jolla Institute for Immunology · US
Funding
Virology CoreP30AI027763 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STEVEN Grant DEEKS · 1988 to 2026
$93.6MFunctionally distinct human CD4 T cell responses to novel evolutionarily selected M. tuberculosis antigensR01AI173002 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joel D. Ernst · 2023 to 2026
$3.4MPersistent Functional Immune Defects in Treated HIV InfectionK24AI145806 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUNT, PETER W · 2020 to 2024
$921kNIAID NIH HHS K24 AI145806NIAID NIH HHS P30 AI027763NIAID NIH HHS R01 AI173002
6 · The paper itselfAbstract
Background: Interleukin 17 producing CD4 T cells contribute to the control of Methods: We performed high-definition characterization of circulating Results: We identified two subsets of Th17 cells: subset 1 defined as CD4 Conclusions: We found differential effects of ART-suppressed HIV on distinct subsets of Th17 cells, that IL17-producing CD4 T cells dominate responses to
Indexed as
antigen-responsive3ART-suppressed6CD4 T-cells2HIV7immunity4Interleukin-171kynurenine pathway8Tuberculosis5
Identifiers
PMID36711855
PMCPMC9881994
OpenAlexW4313702002
What OpenQuestion holds
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LicenceCC BY-NC-ND
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