Evidence map›Paper›PMID 36711839›Full record

ArticlebioRxiv : the preprint server for biology2023

Gut-associated lymphoid tissue attrition associates with response to anti-α4β7 therapy in ulcerative colitis.

Pablo Canales-Herrerias, Mathieu Uzzan, Akihiro Seki, Rafael S Czepielewski, Bram Verstockt, Alexandra Livanos, Fiona Raso, Alexandra Dunn, Daniel Dai, Andrew Wang and 31 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 14 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

41 authors at 9 institutions in 4 countries.

Pablo Canales-HerreriasPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Mathieu UzzanPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Akihiro SekiPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Rafael S CzepielewskiDepartment of Pathology, Washington University School of Medicine, St. Louis, MO, USA.
Bram VerstocktDepartment of Gastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium.
Alexandra LivanosPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Fiona RasoDepartment of Pathology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Alexandra DunnPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Daniel DaiPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Andrew WangPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Zainab Al-TaieDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Jerome MartinPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Huaibin M KoDepartment of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Minami TokuyamaPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Michael TankelevichPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Hadar MeringerPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Francesca CossariniPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Divya JhaPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Azra KrekDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
John D PaulsenDepartment of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
M Zuber NakadarDepartment of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Joshua WongDepartment of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Emma C ErlichDepartment of Pathology, Washington University School of Medicine, St. Louis, MO, USA.
Emily J OnuferDivision of Pediatric Surgery, Department of Surgery, St. Louis Children's Hospital, Washington University in St. Louis School of Medicine, St. Louis, MO, USA.
Beth A HelminkDepartment of Surgery, Section of Surgical Oncology, Washington University School of Medicine, St. Louis, MO.
Keshav SharmaPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Adam RosensteinPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Grace ChungHuman Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Travis DawsonHuman Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Julius JuarezTakeda Pharmaceuticals, Cambridge, MA, USA.
Vijay YajnikTakeda Pharmaceuticals, Cambridge, MA, USA.
Andrea CeruttiPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Jeremiah FaithPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Mayte Suarez-FarinasDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Carmen ArgmannDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Francesca PetraliaDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Gwendalyn J RandolphDepartment of Pathology, Washington University School of Medicine, St. Louis, MO, USA.
Alexandros D PolydoridesHenry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Andrea ReboldiDepartment of Pathology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Jean Frederic ColombelHenry D. Janowitz Division of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Saurabh MehandruPrecision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Icahn School of Medicine at Mount Sinai · USWashington University in St. Louis · USTakeda (United States) · USUniversity of Massachusetts Chan Medical School · USInserm · FRInstitució Catalana de Recerca i Estudis Avançats · ESKU Leuven · BESt. Louis Children's Hospital · USUniversité Paris-Est Créteil · FR

Funding

Defining the lymphatic basis of protein losing enteropathy after Fontan palliation or inflammatory gut diseaseDP1DK130660 · NIDDK · WASHINGTON UNIVERSITY · PI RANDOLPH, GWENDALYN J · 2021 to 2025
$3.8M
Training in the Molecular Basis of Autoimmunity and AutoinflammationT32AI132152 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Katherine A. Fitzgerald, Ann Marshak-Rothstein · 2018 to 2026
$1.6M
Training African giant rats as a cheap diagnostic tool for early TB detectionR03AI068044 · NIAID · APOPO VZW · PI WEETJENS, BART J · 2006 to 2008
$170k
NIAID NIH HHS R03 AI068044NIAID NIH HHS T32 AI132152NIDDK NIH HHS DP1 DK130660
6 · The paper itself

Abstract

Targeting the α4β7-MAdCAM-1 axis with vedolizumab (VDZ) is a front-line therapeutic paradigm in ulcerative colitis (UC). However, mechanism(s) of action (MOA) of VDZ remain relatively undefined. Here, we examined three distinct cohorts of patients with UC (n=83, n=60, and n=21), to determine the effect of VDZ on the mucosal and peripheral immune system. Transcriptomic studies with protein level validation were used to study drug MOA using conventional and transgenic murine models. We found a significant decrease in colonic and ileal naïve B and T cells and circulating gut-homing plasmablasts (β7

Identifiers

PMID36711839
PMCPMC9882272
OpenAlexW4317693915

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.