Evidence map›Paper›PMID 36711815›Full record

ArticlebioRxiv : the preprint server for biology2023

Extensive characterization of a Williams Syndrome murine model shows

Kayla R Nygaard, Susan E Maloney, Raylynn G Swift, Katherine B McCullough, Rachael E Wagner, Stuart B Fass, Krassimira Garbett, Karoly Mirnics, Jeremy Veenstra-VanderWeele, Joseph D Dougherty

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Kayla R NygaardDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Susan E MaloneyDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.
Raylynn G SwiftDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Katherine B McCulloughDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Rachael E WagnerDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.
Stuart B FassDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Krassimira GarbettDepartment of Pharmacology, Vanderbilt University.
Karoly MirnicsPsychiatry, Biochemistry & Molecular Biology, Pharmacology & Experimental Neuroscience, Munroe-Meyer Institute for Genetics and Rehabilitation, University of Nebraska Medical Center Omaha, NE 68198-5450.
Jeremy Veenstra-VanderWeeleDepartments of Psychiatry and Pediatrics, Columbia University; New York State Psychiatric Institute; and Center for Autism and the Developing Brain, New York-Presbyterian Hospital.
Joseph D DoughertyDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Washington University in St. Louis · USNebraska Medical Center · USNewYork–Presbyterian Hospital · USVanderbilt University · US

Funding

WUIDDRC Supplement-Supporting the health and well-being of children with intellectual and developmental disability during COVID-19 pandemicP50HD103525 · NICHD · WASHINGTON UNIVERSITY · PI JEFFREY D MILBRANDT · 2020 to 2026
$15.5M
Neocortical Transcriptome Changes in SchizophreniaR01MH067234 · NIMH · VANDERBILT UNIVERSITY · PI MIRNICS, KAROLY · 2003 to 2021
$4.7M
REGULATION OF MAMMALIAN SOCIAL BEHAVIOR BY THE GTF2I FAMILY OF PROTEINSR01MH107515 · NIMH · WASHINGTON UNIVERSITY · PI DOUGHERTY, JOSEPH D · 2016 to 2020
$2.4M
Neurobiological Signatures of Social Dysfunction and Repetitive BehaviorR01MH094604 · NIMH · VANDERBILT UNIVERSITY · PI VEENSTRA-VANDERWEELE, JEREMY · 2011 to 2015
$2.0M
NICHD NIH HHS P50 HD103525NIMH NIH HHS R01 MH067234NIMH NIH HHS R01 MH094604NIMH NIH HHS R01 MH107515
6 · The paper itself

Abstract

Williams Syndrome is a rare neurodevelopmental disorder exhibiting cognitive and behavioral abnormalities, including increased social motivation, risk of anxiety and specific phobias along with perturbed motor function. Williams Syndrome is caused by a microdeletion of 26-28 genes on chromosome 7, including

Identifiers

PMID36711815
PMCPMC9882309
OpenAlexW4317401769

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.