Evidence map›Paper›PMID 36711778›Full record

ArticlebioRxiv : the preprint server for biology2023

A Novel Protein for the Bioremediation of Gadolinium Waste.

Harvey D Lee, Connor J Grady, Katie Krell, Cooper Strebeck, Nathan M Good, N Cecilia Martinez-Gomez, Assaf A Gilad

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Harvey D LeeDepartment of Biomedical Engineering, Michigan State University, East Lansing, MI, United States.
Connor J GradyDepartment of Biomedical Engineering, Michigan State University, East Lansing, MI, United States.
Katie KrellDepartment of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, United States.
Cooper StrebeckDepartment of Mechanical Engineering, Michigan State University, East Lansing, MI, United States.
Nathan M GoodDepartment of Plant and Microbial Biology, University of California, Berkeley, Berkeley, CA, United States.
N Cecilia Martinez-GomezDepartment of Plant and Microbial Biology, University of California, Berkeley, Berkeley, CA, United States.
Assaf A GiladDepartment of Radiology, Michigan State University, East Lansing, MI, United States.

Funding

Training/Dissemination-Resource for Molecular Imaging Agents in Precision MedicineP41EB024495 · NIBIB · UT SOUTHWESTERN MEDICAL CENTER · PI MARTIN G POMPER · 2017 to 2026
$11.8M
Clinically Translatable MRI Reporter Genes and Imaging Methods with Ultra-High Specificity and SensitivityR01EB031008 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI CHRISTIAN T FARRAR · 2021 to 2026
$4.0M
Bioengineering a novel electromagnetic perspective gene as a tool for wireless control of excitable cellsR01NS098231 · NINDS · MICHIGAN STATE UNIVERSITY · PI GILAD, ASSAF A, PELLED, GALIT · 2017 to 2021
$2.6M
Evolution and optimization of synthetic <READ/WRITE> function from and into cells using genetic programmingR01EB030565 · NIBIB · MICHIGAN STATE UNIVERSITY · PI BANZHAF, WOLFGANG, GILAD, ASSAF A · 2021 to 2024
$2.3M
Semi-synthetic, magneto-photonic circuit for non-invasive control of cellular functionR01EB031936 · NIBIB · CENTRAL MICHIGAN UNIVERSITY · PI GILAD, ASSAF A, HOCHGESCHWENDER, UTE H · 2021 to 2021
$2.0M
Molecular Imaging for Detection of Synthetic Biology Circuits, Oscillators and Toggle Switches in Regenerative MedicineR01NS104306 · NINDS · MICHIGAN STATE UNIVERSITY · PI GILAD, ASSAF A · 2018 to 2021
$1.3M
NIBIB NIH HHS P41 EB024495NIBIB NIH HHS R01 EB030565NIBIB NIH HHS R01 EB031008NIBIB NIH HHS R01 EB031936NINDS NIH HHS R01 NS098231NINDS NIH HHS R01 NS104306
6 · The paper itself

Abstract

Several hundreds of tons of gadolinium-based contrast agents (GBCAs) are being dumped into the environment every year. Although macrocyclic GBCAs exhibit superior stability compared to their linear counterparts, we have found that the structural integrity of chelates are susceptible to ultraviolet light, regardless of configuration. In this study, we present a synthetic protein termed GLamouR that binds and reports gadolinium in an intensiometric manner. We then explore the extraction of gadolinium from GBCA-spiked artificial urine samples and investigate if the low picomolar concentrations reported in gadolinium-contaminated water sources pose a barrier for bioremediation. Based on promising results, we anticipate GLamouR can be used for detecting and mining REEs beyond gadolinium as well and hope to expand the biological toolbox for such applications.

Identifiers

PMID36711778
PMCPMC9881998

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.