Evidence map›Paper›PMID 36711773›Full record

ArticlebioRxiv : the preprint server for biology2023

Functional gene delivery to and across brain vasculature of systemic AAVs with endothelial-specific tropism in rodents and broad tropism in primates.

Xinhong Chen, Damien A Wolfe, Dhanesh Sivadasan Bindu, Mengying Zhang, Naz Taskin, David Goertsen, Timothy F Shay, Erin Sullivan, Sheng-Fu Huang, Sripriya Ravindra Kumar and 20 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 13 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

30 authors at 7 institutions in 3 countries.

Xinhong ChenDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA.
Damien A WolfeDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA.
Dhanesh Sivadasan BinduDepartment of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA.
Mengying ZhangDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA.
Naz TaskinAllen Institute for Brain Science, Seattle, WA, USA.
David GoertsenDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA.
Timothy F ShayDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA.
Erin SullivanDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA.
Sheng-Fu HuangDepartment of Neurosurgery, Clinical Neuroscience Center, Zurich University Hospital, University of Zurich, Zurich, Switzerland.
Sripriya Ravindra KumarDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA.
Cynthia M ArokiarajDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA.
Viktor PlattnerSainsbury Wellcome Centre, University College London, London, UK.
Lillian J CamposDepartment of Psychology and California National Primate Research Center, University of California, Davis, Davis, CA, 95616, USA.
John MichAllen Institute for Brain Science, Seattle, WA, USA.
Deja MonetAllen Institute for Brain Science, Seattle, WA, USA.
Victoria NgoCortical Systems and Behavior Lab, University of California San Diego, La Jolla, CA, 92039, USA.
Xiaozhe DingDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA.
Victoria OmsteadAllen Institute for Brain Science, Seattle, WA, USA.
Natalie WeedAllen Institute for Brain Science, Seattle, WA, USA.
Yeme BishawAllen Institute for Brain Science, Seattle, WA, USA.
Bryan GoreAllen Institute for Brain Science, Seattle, WA, USA.
Ed S LeinAllen Institute for Brain Science, Seattle, WA, USA.
Athena AkramiSainsbury Wellcome Centre, University College London, London, UK.
Cory MillerCortical Systems and Behavior Lab, University of California San Diego, La Jolla, CA, 92039, USA.
Boaz P LeviAllen Institute for Brain Science, Seattle, WA, USA.
Annika KellerDepartment of Neurosurgery, Clinical Neuroscience Center, Zurich University Hospital, University of Zurich, Zurich, Switzerland.
Jonathan T TingAllen Institute for Brain Science, Seattle, WA, USA.
Andrew S FoxDepartment of Psychology and California National Primate Research Center, University of California, Davis, Davis, CA, 95616, USA.
Cagla ErogluDepartment of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA.
Viviana GradinaruDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA.
Allen Institute for Brain Science · USCalifornia Institute of Technology · USDuke University · USSainsbury Laboratory · GBUniversity of California, Davis · USUniversity of California San Diego · USUniversity of Zurich · CH

Funding

National Institute on Aging (NIA) ColonyP51OD011107 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Simon J. Atkinson · 2012 to 2026
$191.5M
Comprehensive Structural and Functional Mapping of Mammalian Colonic Nervous SystemOT2OD024899 · OD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MULUGETA, MILLION, TACHE, YVETTE FRANCE · 2017 to 2021
$13.1M
Novel Genetically Encoded Indicators for Interrogating Neuron-Astrocyte Communication Across TimescalesU19NS123719 · NINDS · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI TIAN, LIN · 2021 to 2025
$10.7M
Engineered AAV Identification, Validation, and Dissemination Pipeline for Brain Cell Type-Specific Manipulation Across SpeciesUF1MH128336 · NIMH · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI FOX, ANDREW S, GRADINARU, VIVIANA · 2021 to 2021
$6.1M
Circuit-Specific Delivery of Large Cargo Across the Nervous Systems of Adult Mammals and Embryos via Novel Engineered Systemic VectorsDP1NS111369 · NINDS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI GRADINARU, VIVIANA · 2018 to 2023
$5.9M
Neuromodulation and Neurodegeneration: the Missing Link and Mechanisms of ActionDP2NS087949 · NINDS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI GRADINARU, VIVIANA · 2013 to 2019
$4.1M
Cell type selective viral tools to interrogate and correct non-human primate and human brain circuitryUG3MH120095 · NIMH · ALLEN INSTITUTE · PI KALUME, FRANCK K, LEIN, ED · 2020 to 2022
$3.8M
Multiplex interrogation of neuromodulatory signaling in behaving animals with enhanced depth and resolutionU01NS120820 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI TIAN, LIN, VONZASTROW, MARK E · 2021 to 2024
$3.5M
New Proteomic and Genome Engineering Approaches to Decipher Astrocyte Function at SynapsesR01DA047258 · NIDA · DUKE UNIVERSITY · PI EROGLU, CAGLA, SODERLING, SCOTT H · 2018 to 2020
$2.1M
Control of Astrocyte Development and Astrocyte-Synapse InteractionsR01NS102237 · NINDS · DUKE UNIVERSITY · PI EROGLU, CAGLA · 2018 to 2022
$1.9M
NIDA NIH HHS R01 DA047258NIH HHS OT2 OD024899NIH HHS P51 OD011107NIMH NIH HHS UF1 MH128336NIMH NIH HHS UG3 MH120095NINDS NIH HHS DP1 NS111369NINDS NIH HHS DP2 NS087949NINDS NIH HHS R01 NS102237NINDS NIH HHS U01 NS120820NINDS NIH HHS U19 NS123719
6 · The paper itself

Abstract

Delivering genes to and across the brain vasculature efficiently and specifically across species remains a critical challenge for addressing neurological diseases. We have evolved adeno-associated virus (AAV9) capsids into vectors that transduce brain endothelial cells specifically and efficiently following systemic administration in wild-type mice with diverse genetic backgrounds and rats. These AAVs also exhibit superior transduction of the CNS across non-human primates (marmosets and rhesus macaques), and

Identifiers

PMID36711773
PMCPMC9882234
OpenAlexW4316020014

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.