Evidence map›Paper›PMID 36711729›Full record

ArticlebioRxiv : the preprint server for biology2023

Modulation of protein-DNA binding reveals mechanisms of spatiotemporal gene control in early

Sahla Syed, Yifei Duan, Bomyi Lim

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Sahla SyedDepartment of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA 19104.
Yifei DuanDepartment of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA 19104.
Bomyi LimDepartment of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA 19104.
University of Pennsylvania · US

Funding

Design principles and dynamic gene control in embryonic developmentR35GM133425 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Bomyi Lim · 2019 to 2026
$2.9M
NIGMS NIH HHS R35 GM133425
6 · The paper itself

Abstract

It is well known that enhancers regulate the spatiotemporal expression of their target genes by recruiting transcription factors (TFs) to the cognate binding sites in the region. However, the role of multiple binding sites for the same TFs and their specific spatial arrangement in determining the overall competency of the enhancer has yet to be fully understood. In this study, we utilized the MS2-MCP live imaging technique to quantitatively analyze the regulatory logic of the

Indexed as

burstingHidden Markov modellive imagingMS2-MCPtranscription factorsTranscription kinetics

Identifiers

PMID36711729
PMCPMC9881968
OpenAlexW4313551411

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.