Evidence map›Paper›PMID 36711720›Full record

ArticlemedRxiv : the preprint server for health sciences2023

A Moving Target: Impacts of Lowering Viral Load Suppression Cutpoints on Progress Towards HIV Epidemic Control Goals.

Joseph G Rosen, Steven J Reynolds, Ronald M Galiwango, Godfrey Kigozi, Thomas C Quinn, Oliver Ratmann, Anthony Ndyanabo, Lisa J Nelson, Gertrude Nakigozi, Margaret Nalugemwa and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Joseph G RosenDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Steven J ReynoldsRakai Health Sciences Program, Entebbe, Uganda.
Ronald M GaliwangoRakai Health Sciences Program, Entebbe, Uganda.
Godfrey KigoziRakai Health Sciences Program, Entebbe, Uganda.
Thomas C QuinnRakai Health Sciences Program, Entebbe, Uganda.
Oliver RatmannDepartment of Mathematics, Imperial College, London, United Kingdom.
Anthony NdyanaboRakai Health Sciences Program, Entebbe, Uganda.
Lisa J NelsonCenters for Disease Control and Prevention, Kampala, Uganda.
Gertrude NakigoziRakai Health Sciences Program, Entebbe, Uganda.
Margaret NalugemwaRakai Health Sciences Program, Entebbe, Uganda.
Katherine B RucinskiDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Caitlin E KennedyDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Larry W ChangDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Joseph KagaayiRakai Health Sciences Program, Entebbe, Uganda.
David SerwaddaRakai Health Sciences Program, Entebbe, Uganda.
M Kate GrabowskiRakai Health Sciences Program, Entebbe, Uganda.

Funding

Circumcision: HIV/STIs and behaviors in a RCT and post-RCT surveillance; RakaiU01AI075115 · NIAID · JOHNS HOPKINS UNIVERSITY · PI GRAY, RONALD H · 2007 to 2011
$9.3M
Johns Hopkins HIV Epidemiology and Prevention Sciences Training ProgramT32AI102623 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Shruti H Mehta · 2013 to 2026
$5.3M
The role of penile bacteria and inflammation in HIV susceptibility; Rakai, UgandaR01AI123002 · NIAID · GEORGE WASHINGTON UNIVERSITY · PI LIU, CINDY · 2016 to 2020
$3.3M
Enhanced Provision of Male Circumcision for HIV Prevention, Rakai, UgandaU01AI100031 · NIAID · JOHNS HOPKINS UNIVERSITY · PI GRAY, RONALD H · 2012 to 2014
$3.2M
Hard-to-Reach Populations: Implications for Ending the AIDS EpidemicR01AI143333 · NIAID · JOHNS HOPKINS UNIVERSITY · PI CHANG, LARRY WILLIAM · 2019 to 2022
$2.4M
HIV Incidence, Transmission Dynamics and Combination HIV Prevention: Rakai UgandaR01AI110324 · NIAID · JOHNS HOPKINS UNIVERSITY · PI GRAY, RONALD H · 2014 to 2016
$2.4M
Penile Microbiome, Inflammation and HIV Susceptibility During Sexual Debut and Maturation Among Male AdolescentsR01AI128779 · NIAID · JOHNS HOPKINS UNIVERSITY · PI TOBIAN, AARON A · 2017 to 2020
$2.1M
Understanding HIV risk and service use in hotspot Ugandan fishing communitiesR01MH105313 · NIMH · JOHNS HOPKINS UNIVERSITY · PI KENNEDY, CAITLIN E · 2015 to 2017
$1.1M
Implementation Research to Optimize ART Delivery for Adolescents and Young Adults Living with HIVK01MH129226 · NIMH · JOHNS HOPKINS UNIVERSITY · PI Katherine B Rucinski · 2022 to 2026
$792k
Viral Load Trajectories and Dynamics among People Living with HIV in Rakai, Uganda: A Mixed-Methods StudyF31MH126796 · NIMH · JOHNS HOPKINS UNIVERSITY · PI ROSEN, JOSEPH GREGORY · 2021 to 2022
$79k
NIAID NIH HHS R01 AI110324NIAID NIH HHS R01 AI123002NIAID NIH HHS R01 AI128779NIAID NIH HHS R01 AI143333NIAID NIH HHS T32 AI102623NIAID NIH HHS U01 AI075115NIAID NIH HHS U01 AI100031NIMH NIH HHS F31 MH126796NIMH NIH HHS K01 MH129226NIMH NIH HHS R01 MH105313
6 · The paper itself

Abstract

Redefining viral load suppression (VLS) using lower cutpoints could impact progress towards the UNAIDS 95-95-95 targets. We assessed impacts of lowering the VLS cutpoint on achieving the 95-95-95 VLS target in the Rakai Community Cohort Study. Population VLS fell from 86% to 84% and 76%, respectively, after lowering VLS cutpoints from <1,000 to <200 and <50 copies/mL. The fraction of viremic persons increased by 17% after lowering the VLS cutpoint from <1,000 to <200 copies/mL.

Identifiers

PMID36711720
PMCPMC9882556

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.