Evidence map›Paper›PMID 36711707›Full record

ArticlebioRxiv : the preprint server for biology2023

Michelle Y Fry, Paula P Navarro, Pusparanee Hakim, Virly Y Ananda, Xingping Qin, Juan C Landoni, Sneha Rath, Zintis Inde, Camila Makhlouta Lugo, Bridget E Luce and 8 more

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 11 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 3 countries.

Michelle Y FryDepartment of Molecular Biology, Massachusetts General Hospital, Boston, USA.ORCID 0000-0002-3209-5492
Paula P NavarroDepartment of Molecular Biology, Massachusetts General Hospital, Boston, USA.ORCID 0000-0002-9123-1132
Pusparanee HakimDepartment of Molecular Biology, Massachusetts General Hospital, Boston, USA.ORCID 0000-0002-9018-8179
Virly Y AnandaDepartment of Molecular Biology, Massachusetts General Hospital, Boston, USA.ORCID 0000-0001-5590-1170
Xingping QinJohn B. Little Center for Radiation Sciences, Harvard T.H. Chan School of Public Health, Boston, USA.ORCID 0000-0003-3263-0843
Juan C LandoniInstitute of Physics, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.ORCID 0000-0002-0318-6707
Sneha RathDepartment of Molecular Biology, Massachusetts General Hospital, Boston, USA.ORCID 0000-0001-8839-1285
Zintis IndeJohn B. Little Center for Radiation Sciences, Harvard T.H. Chan School of Public Health, Boston, USA.ORCID 0000-0001-5564-1698
Camila Makhlouta LugoDepartment of Molecular Biology, Massachusetts General Hospital, Boston, USA.ORCID 0000-0003-4655-8096
Bridget E LuceDepartment of Molecular Biology, Massachusetts General Hospital, Boston, USA.ORCID 0000-0002-0107-5181
Yifan GeDepartment of Molecular Biology, Massachusetts General Hospital, Boston, USA.ORCID 0000-0001-9135-9569
Julie L McDonaldDepartment of Molecular Biology, Massachusetts General Hospital, Boston, USA.ORCID 0000-0002-3715-9619
Ilzat AliDepartment of Molecular Biology, Massachusetts General Hospital, Boston, USA.
Leillani L HaCenter for Genomic Medicine, Massachusetts General Hospital, Boston, USA.ORCID 0000-0003-4478-660X
Benjamin P KleinstiverCenter for Genomic Medicine, Massachusetts General Hospital, Boston, USA.ORCID 0000-0002-5469-0655
David C ChanDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, USA.ORCID 0000-0002-0191-2154
Kristopher A SarosiekJohn B. Little Center for Radiation Sciences, Harvard T.H. Chan School of Public Health, Boston, USA.
Luke H ChaoDepartment of Molecular Biology, Massachusetts General Hospital, Boston, USA.ORCID 0000-0002-4849-4148
Harvard University · USMassachusetts General Hospital · USCalifornia Institute of Technology · USÉcole Polytechnique Fédérale de Lausanne · CH

Funding

Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI RAYMOND T CHUNG · 1991 to 2026
$35.3M
Transgenic CoreP30DK057521 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI KAHN, BARBARA B. · 2000 to 2019
$31.4M
Training Program in Molecular and Integrative Physiological SciencesT32HL007118 · NHLBI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI LU, QUAN · 1985 to 2025
$14.3M
Probing structural and biophysical mechanisms of mitochondrial membrane ultrastructureR35GM142553 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI Luke H. Chao · 2021 to 2026
$2.6M
Developmental regulation of apoptosis as a modifiable driver of radiotherapy-induced neurocognitive impairment in pediatric patientsR37CA248565 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Kristopher Andrew Sarosiek · 2020 to 2026
$2.6M
Identifying targetable apoptotic vulnerabilities for the treatment of AL amyloidosisR01DK125263 · NIDDK · HARVARD SCHOOL OF PUBLIC HEALTH · PI SAROSIEK, KRISTOPHER ANDREW · 2020 to 2023
$1.4M
Apoptotic Regulation and Neuroinflammation in Alzheimer's DiseaseF32AG077861 · NIA · HARVARD SCHOOL OF PUBLIC HEALTH · PI INDE, ZINTIS · 2022 to 2022
$68k
NCI NIH HHS R37 CA248565NHLBI NIH HHS T32 HL007118NIA NIH HHS F32 AG077861NIDDK NIH HHS P30 DK043351NIDDK NIH HHS P30 DK057521NIDDK NIH HHS R01 DK125263NIGMS NIH HHS R35 GM142553
6 · The paper itself

Abstract

Cristae membrane state plays a central role in regulating mitochondrial function and cellular metabolism. The protein Optic atrophy 1 (Opa1) is an important crista remodeler that exists as two forms in the mitochondrion, a membrane-anchored long form (l-Opa1) and a processed short form (s-Opa1). The mechanisms for how Opa1 influences cristae shape have remained unclear due to lack of native three-dimensional views of cristae. We perform

Indexed as

Cristae remodelingCryo-electron tomographyCryo-focused ion beam millingMitochondrial biology

Identifiers

PMID36711707
PMCPMC9882235
OpenAlexW4317209797

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.