Evidence map›Paper›PMID 36711702›Full record

ArticlebioRxiv : the preprint server for biology2023

Macrophage activation drives ovarian failure and masculinization.

Paloma Bravo, Yulong Liu, Bruce W Draper, Florence L Marlow

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Paloma BravoDepartment of Cell, Developmental and Regenerative Biology. Icahn School of Medicine at Mount Sinai; New York, NY, USA.
Yulong LiuDepartment of Molecular and Cellular Biology. University of California; Davis, CA, USA.
Bruce W DraperDepartment of Molecular and Cellular Biology. University of California; Davis, CA, USA.
Florence L MarlowDepartment of Cell, Developmental and Regenerative Biology. Icahn School of Medicine at Mount Sinai; New York, NY, USA.
New York Proton Center · USUniversity of California, Davis · US

Funding

Molecular genetic basis of sex-specific differentiation of germ cellsR01GM133896 · NIGMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MARLOW, FLORENCE LOUISE · 2020 to 2023
$1.9M
NIGMS NIH HHS R01 GM133896
6 · The paper itself

Abstract

In humans, premature ovarian insufficiency (POI) is caused by autoimmunity and genetic factors, such as mutation of BMP15, a key ovarian determining gene. The cellular mechanisms associated with ovarian failure caused by BMP15 mutation and immune contributions to the disorder are not understood. BMP15's role in ovarian follicle development is conserved in vertebrates, including zebrafish. Using zebrafish, we established a causal link between macrophage activation and ovarian failure. We identified a germline-somatic gonadal cell-macrophage axis underlying ovarian atresia. Germline loss of Bmp15 triggers this axis that single-cell RNA sequencing and genetic analyses indicate involves activation of ovarian somatic cells that express conserved macrophage-activating ligands. Genetic ablation of macrophages blocks premature oocyte loss. Thus, the axis identified here represents potential therapeutic targets to preserve female fertility.

Identifiers

PMID36711702
PMCPMC9881905
OpenAlexW4313456524

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.