Evidence map›Paper›PMID 36711700›Full record

ArticlebioRxiv : the preprint server for biology2023

Conserved Roles for the Dynein Intermediate Chain and Ndel1 in Assembly and Activation of Dynein.

Kyoko Okada, Bharat R Iyer, Lindsay G Lammers, Pedro Gutierrez, Wenzhe Li, Steven M Markus, Richard J McKenney

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 9 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Kyoko OkadaDepartment of Molecular and Cellular Biology, University of California, Davis, Davis, CA, USA.
Bharat R IyerDepartment of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO, USA.
Lindsay G LammersDepartment of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO, USA.
Pedro GutierrezDepartment of Molecular and Cellular Biology, University of California, Davis, Davis, CA, USA.
Wenzhe LiDepartment of Molecular and Cellular Biology, University of California, Davis, Davis, CA, USA.
Steven M MarkusDepartment of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO, USA.
Richard J McKenneyDepartment of Molecular and Cellular Biology, University of California, Davis, Davis, CA, USA.
University of California, Davis · USColorado State University · US

Funding

Coordination of molecular motor activity in intracellular transport and assembly of cytoskeletal architecture.R35GM124889 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Richard James McKenney · 2017 to 2026
$4.3M
Regulation of Dynein-Mediated Transport.R35GM139483 · NIGMS · COLORADO STATE UNIVERSITY · PI Steven M Markus · 2021 to 2026
$2.9M
Regulation of Cytoplasmic Dynein Motility in Neuronal TransportR00NS089428 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MCKENNEY, RICHARD JAMES · 2016 to 2018
$736k
NIGMS NIH HHS R35 GM124889NIGMS NIH HHS R35 GM139483NINDS NIH HHS R00 NS089428
6 · The paper itself

Abstract

Cytoplasmic dynein, the primary retrograde microtubule transport motor within cells, must be activated for processive motility through the regulated assembly of a dynein-dynactin-adapter (DDA) complex. The interaction between dynein and dynactin was initially ascribed to the N-terminus of the dynein intermediate chain (IC) and a coiled-coil of the dynactin subunit p150

Identifiers

PMID36711700
PMCPMC9882231
OpenAlexW4316185003

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.