Evidence map›Paper›PMID 36711676›Full record

ArticlebioRxiv : the preprint server for biology2023

Reinforcement Learning informs optimal treatment strategies to limit antibiotic resistance.

Davis T Weaver, Eshan S King, Jeff Maltas, Jacob G Scott

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Davis T WeaverCase Western Reserve University School of Medicine, Cleveland, OH, 44106, USA.ORCID 0000-0003-3086-497X
Eshan S KingCase Western Reserve University School of Medicine, Cleveland, OH, 44106, USA.ORCID 0000-0002-0345-3780
Jeff MaltasTranslational Hematology Oncology Research, Cleveland Clinic, Cleveland OH, 44106, USA.ORCID 0000-0001-6567-6800
Jacob G ScottCase Western Reserve University School of Medicine, Cleveland, OH, 44106, USA.ORCID 0000-0003-2971-7673

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007250 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI HUANG, ALEX YEE-CHEN · 1985 to 2023
$33.4M
Exploiting Ecology and Evolution to Prevent Therapy Resistance in EGFR-Driven Lung CancerR37CA244613 · NCI · CLEVELAND CLINIC LERNER COM-CWRU · PI Jacob Gardinier Scott · 2020 to 2026
$4.0M
Computational Genomic Epidemiology of Cancer (CoGEC) Training ProgramT32CA094186 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI Thomas Louis LaFramboise, Rong Xu · 2017 to 2026
$2.6M
NCI NIH HHS R37 CA244613NCI NIH HHS T32 CA094186NIGMS NIH HHS T32 GM007250
6 · The paper itself

Abstract

Antimicrobial resistance was estimated to be associated with 4.95 million deaths worldwide in 2019. It is possible to frame the antimicrobial resistance problem as a feedback-control problem. If we could optimize this feedback-control problem and translate our findings to the clinic, we could slow, prevent or reverse the development of high-level drug resistance. Prior work on this topic has relied on systems where the exact dynamics and parameters were known

Identifiers

PMID36711676
PMCPMC9882109

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.