Evidence map›Paper›PMID 36711654›Full record

ArticlebioRxiv : the preprint server for biology2023

Sexual dimorphism in obesity is governed by RELMα regulation of adipose macrophages and eosinophils.

Jiang Li, Rebecca E Ruggiero-Ruff, Yuxin He, Xinru Qiu, Nancy M Lainez, Pedro A Villa, Adam Godzik, Djurdjica Coss, Meera G Nair

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Jiang LiDivision of Biomedical Sciences, School of Medicine, University of California Riverside, Riverside, CA, USA.
Rebecca E Ruggiero-RuffDivision of Biomedical Sciences, School of Medicine, University of California Riverside, Riverside, CA, USA.
Yuxin HeDivision of Biomedical Sciences, School of Medicine, University of California Riverside, Riverside, CA, USA.
Xinru QiuGraduate Program in Genetics, Genomics and Bioinformatics, University of California Riverside, Riverside, CA, USA.
Nancy M LainezDivision of Biomedical Sciences, School of Medicine, University of California Riverside, Riverside, CA, USA.
Pedro A VillaDivision of Biomedical Sciences, School of Medicine, University of California Riverside, Riverside, CA, USA.
Adam GodzikDivision of Biomedical Sciences, School of Medicine, University of California Riverside, Riverside, CA, USA.
Djurdjica CossDivision of Biomedical Sciences, School of Medicine, University of California Riverside, Riverside, CA, USA.
Meera G NairDivision of Biomedical Sciences, School of Medicine, University of California Riverside, Riverside, CA, USA.

Funding

RELMalpha-expressing macrophages mediate host disease tolerance in mucosal infectionR01AI153195 · NIAID · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI NAIR, MEERA GOH · 2020 to 2024
$3.5M
The Role of AP1 Family Members in Hormone Gene ExpressionR01HD091167 · NICHD · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI COSS, DJURDJICA · 2018 to 2022
$1.7M
Illumina NovaSeq 6000 Sequencing SystemS10OD026929 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JEPSEN, KRISTEN LYNN · 2019 to 2019
$600k
NIAID NIH HHS R01 AI153195NICHD NIH HHS R01 HD091167NIH HHS S10 OD026929
6 · The paper itself

Abstract

Obesity incidence is increasing worldwide with the urgent need to identify new therapeutics. Sex differences in immune cell activation drive obesity-mediated pathologies where males are more susceptible to obesity co-morbidities and exacerbated inflammation. Here, we demonstrate that the macrophage-secreted protein RELMα critically protects females against high fat diet-induced obesity. Compared to male mice, RELMα levels were elevated in both control and high fat dietfed females and correlated with adipose macrophages and eosinophils. RELMα-deficient females gained more weight and had pro-inflammatory macrophage accumulation and eosinophil loss, while both RELMα treatment and eosinophil transfer rescued this phenotype. Single cell RNA-sequencing of the adipose stromal vascular fraction was performed and identified sex and RELMα-dependent changes. Genes involved in oxygen sensing and iron homeostasis, including hemoglobin and lncRNA Gm47283, correlated with increased obesity, while eosinophil chemotaxis and response to amyloid-beta were protective. Monocyte-to-macrophage transition was also dysregulated in RELMα-deficient animals. Collectively, these studies implicate a RELMα-macrophage-eosinophil axis in sex-specific protection against obesity and uncover new therapeutic targets for obesity.

Identifiers

PMID36711654
PMCPMC9882128

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.