Evidence map›Paper›PMID 36711653›Full record

ArticlebioRxiv : the preprint server for biology2023

APOE4, Age & Sex Regulate Respiratory Plasticity Elicited By Acute Intermittent Hypercapnic-Hypoxia.

Jayakrishnan Nair, Joseph F Welch, Alexandria B Marciante, Tingting Hou, Qing Lu, Emily J Fox, Gordon S Mitchell

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Jayakrishnan NairBreathing Research and Therapeutics Center Department of Physical Therapy, University of Florida.
Joseph F WelchBreathing Research and Therapeutics Center Department of Physical Therapy, University of Florida.
Alexandria B MarcianteBreathing Research and Therapeutics Center Department of Physical Therapy, University of Florida.
Tingting HouDepartment of Biostatistics, University of Florida.
Qing LuDepartment of Biostatistics, University of Florida.
Emily J FoxBreathing Research and Therapeutics Center Department of Physical Therapy, University of Florida.
Gordon S MitchellBreathing Research and Therapeutics Center Department of Physical Therapy, University of Florida.
University of Florida · USThomas Jefferson University · US

Funding

Microglial regulation of intermittent hypoxia induced phrenic motor plasticityR01HL149800 · NHLBI · UNIVERSITY OF FLORIDA · PI MITCHELL, GORDON S. · 2020 to 2025
$4.2M
Breathing Research and Therapeutics (BREATHE)T32HL134621 · NHLBI · UNIVERSITY OF FLORIDA · PI Gordon S. Mitchell · 2017 to 2026
$3.4M
Regulation of Intermittent Hypoxia-Induced Respiratory Motor PlasticityR01HL148030 · NHLBI · UNIVERSITY OF FLORIDA · PI MITCHELL, GORDON S. · 2019 to 2022
$2.4M
NHLBI NIH HHS R01 HL148030NHLBI NIH HHS R01 HL149800NHLBI NIH HHS T32 HL134621
6 · The paper itself

Abstract

Rationale: Acute intermittent hypoxia (AIH) is a promising strategy to induce functional motor recovery following chronic spinal cord injuries and neurodegenerative diseases. Although significant results are obtained, human AIH trials report considerable inter-individual response variability. Objectives: Identify individual factors ( Methods: Associations of individual factors with the magnitude of AIHH (15, 1-min O Results: AIHH-induced changes in diaphragm MEP amplitudes were lower in individuals heterozygous for Conclusions: ADDITION TO KNOWLEDGE BASE: Acute intermittent hypoxia (AIH) is a novel rehabilitation strategy to induce functional recovery of respiratory and non-respiratory motor systems in people with chronic spinal cord injury and/or neurodegenerative diseases. Since most AIH trials report considerable inter-individual variability in AIH outcomes, we investigated factors that potentially undermine the response to an optimized AIH protocol, acute intermittent hypercapnic-hypoxia (AIHH), in healthy humans. We demonstrate that genetics (particularly the lipid transporter,

Identifiers

PMID36711653
PMCPMC9881941
OpenAlexW4313705323

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.