Evidence map›Paper›PMID 36711651›Full record

ArticlebioRxiv : the preprint server for biology2023

Sex differences in adolescent cannabis vapor self-administration mediate enduring effects on behavioral flexibility and prefrontal microglia activation in rats.

Timothy G Freels, Sara R Westbrook, Hayden R Wright, Jacqulyn R Kuyat, Erica Zamberletti, Alexandra M Malena, Max W Melville, Amanda M Brown, Nicholas C Glodosky, Darren E Ginder and 4 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 9 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 2 countries.

Timothy G FreelsDepartment of Integrative Physiology and Neuroscience, Washington State University, Pullman, WA, USA.
Sara R WestbrookDepartment of Integrative Physiology and Neuroscience, Washington State University, Pullman, WA, USA.
Hayden R WrightDepartment of Integrative Physiology and Neuroscience, Washington State University, Pullman, WA, USA.
Jacqulyn R KuyatDepartment of Integrative Physiology and Neuroscience, Washington State University, Pullman, WA, USA.
Erica ZamberlettiDepartment of Biotechnology and Life Sciences and Neuroscience Center, University of Insubria, Busto Arsizio, Varese, Italy.
Alexandra M MalenaDepartment of Integrative Physiology and Neuroscience, Washington State University, Pullman, WA, USA.
Max W MelvilleDepartment of Integrative Physiology and Neuroscience, Washington State University, Pullman, WA, USA.
Amanda M BrownDepartment of Integrative Physiology and Neuroscience, Washington State University, Pullman, WA, USA.
Nicholas C GlodoskyDepartment of Psychology, Washington State University, Pullman, WA, USA.
Darren E GinderDepartment of Psychology, Washington State University, Pullman, WA, USA.
Courtney M KlappenbachDepartment of Integrative Physiology and Neuroscience, Washington State University, Pullman, WA, USA.
Kristen M DelevichDepartment of Integrative Physiology and Neuroscience, Washington State University, Pullman, WA, USA.
Tiziana RubinoDepartment of Biotechnology and Life Sciences and Neuroscience Center, University of Insubria, Busto Arsizio, Varese, Italy.
Ryan J McLaughlinDepartment of Integrative Physiology and Neuroscience, Washington State University, Pullman, WA, USA.
Washington State University · USUniversity of Insubria · IT

Funding

Effects of developmental cannabis exposure on prefrontocortical structure and functionR21DA043722 · NIDA · WASHINGTON STATE UNIVERSITY · PI MCLAUGHLIN, RYAN JOSEPH · 2017 to 2018
$421k
NIDA NIH HHS R21 DA043722
6 · The paper itself

Abstract

Cannabis is the most used illicit drug in the United States. With many states passing legislation to permit its recreational use, there is concern that cannabis use among adolescents could increase dramatically in the coming years. Historically, it has been difficult to model real-world cannabis use to investigate the causal relationship between cannabis use in adolescence and behavioral and neurobiological effects in adulthood. To this end, we used a novel volitional vapor administration model to investigate long-term effects of cannabis use during adolescence on the medial prefrontal cortex (mPFC) and mPFC-dependent behaviors in male and female rats. Adolescent (35-55 day old) female rats had significantly higher rates of responding for vaporized Δ

Indexed as

adolescencebehavioral flexibilitycannabismicrogliaratvapor

Identifiers

PMID36711651
PMCPMC9882275
OpenAlexW4317716336

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.