Evidence map›Paper›PMID 36711616›Full record

ArticlemedRxiv : the preprint server for health sciences2023

The impact of early life experiences and gut microbiota on neurobehavioral development among preterm infants: A longitudinal cohort study.

Jie Chen, Hongfei Li, Tingting Zhao, Kun Chen, Ming-Hui Chen, Zhe Sun, Wanli Xu, Kendra Maas, Barry Lester, Xiaomei Cong

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Jie ChenFlorida State University College of Nursing, Tallahassee, FL., United States.ORCID 0000-0002-1568-8974
Hongfei LiDepartment of Statistics, University of Connecticut, Storrs, CT., United States.ORCID 0000-0001-5359-2853
Tingting ZhaoSchool of Nursing, University of Connecticut, Storrs, CT., United States.
Kun ChenDepartment of Statistics, University of Connecticut, Storrs, CT., United States.
Ming-Hui ChenDepartment of Statistics, University of Connecticut, Storrs, CT., United States.ORCID 0000-0003-1935-2447
Zhe SunDepartment of Statistics, University of Connecticut, Storrs, CT., United States.
Wanli XuSchool of Nursing, University of Connecticut, Storrs, CT., United States.ORCID 0000-0001-5664-6685
Kendra MaasUniversity of Connecticut, Microbial Analysis, Resources, and Services (MARS), Storrs, CT., United States.
Barry LesterBrown Center for the Study of Children at Risk, Departments of Psychiatry and Pediatrics, Warren Alpert Medical School of Brown University, Providence, RI., United States.
Xiaomei CongYale University School of Nursing, Orange, CT., United States.ORCID 0000-0002-4992-199X
University of Connecticut · USBrown University · USFlorida State University · US

Funding

Multi-Omics Analysis of Pain/Stress Impact on Neurodevelopment in Preterm InfantsR01NR016928 · NINR · UNIVERSITY OF CONNECTICUT STORRS · PI CONG, XIAOMEI SOPHIA · 2017 to 2020
$2.5M
Early Life Experience Imprints Gut Microbiome in Preterm InfantsK23NR014674 · NINR · UNIVERSITY OF CONNECTICUT STORRS · PI CONG, XIAOMEI SOPHIA · 2013 to 2015
$396k
NINR NIH HHS K23 NR014674NINR NIH HHS R01 NR016928
6 · The paper itself

Abstract

Objectives: To investigate the impact of early life experiences and gut microbiota on neurobehavioral development among preterm infants during neonatal intensive care unit (NICU) hospitalization. Methods: Preterm infants were followed from the NICU admission until their 28 Results: Preterm infants who experienced high level of pain/stress during the NICU hospitalization that were associated with higher NNNS stress/abstinence scores. Eight operational taxonomic units (OTUs) were identified to be associated with of NNNS subscales after controlling demographic and clinical features, feeding patterns, and painful/stressful experiences. These OTUs, taxa belong to seven genera including Conclusions: This study explored the dynamic impact of specific OTUs on neurobehavioral development among preterm infants after controlling for early life experiences, i.e., acute and chronic pain/stress, and feeding in the NICU.

Identifiers

PMID36711616
PMCPMC9882379
OpenAlexW4313682897

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.