Evidence map›Paper›PMID 36711600›Full record

ArticlebioRxiv : the preprint server for biology2023

Indirect enrichment of desirable, but less fit phenotypes, from a synthetic microbial community using microdroplet confinement.

Ramya Ganiga Prabhakar, Gaoyang Fan, Razan N Alnahhas, Andrew J Hirning, Matthew R Bennett, Yousif Shamoo

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Ramya Ganiga PrabhakarDepartment of Biosciences, Rice University, Houston, United States.
Gaoyang FanDepartment of Mathematics, University of Houston, Houston, Texas, United States.
Razan N AlnahhasDepartment of Biomedical Engineering, Boston University, Boston, Massachusetts 02215, United States.
Andrew J HirningDepartment of Biosciences, Rice University, Houston, United States.
Matthew R BennettDepartment of Biosciences, Rice University, Houston, United States.
Yousif ShamooDepartment of Biosciences, Rice University, Houston, United States.ORCID 0000-0001-9241-8962
Rice University · USBoston University · USUniversity of Houston · US

Funding

Defining Evolutionary Trajectories: Molecular adaptation to antibiotic resistanceR01AI080714 · NIAID · RICE UNIVERSITY · PI SHAMOO, YOUSIF · 2009 to 2023
$4.3M
Dynamics and pattern formation in differentiating cellular populationsR01GM144959 · NIGMS · RICE UNIVERSITY · PI BENNETT, MATTHEW R. · 2021 to 2024
$1.2M
NIAID NIH HHS R01 AI080714NIGMS NIH HHS R01 GM144959
6 · The paper itself

Abstract

Spatial structure within microbial communities can provide nearly limitless opportunities for social interactions and are an important driver for evolution. As metabolites are often molecular signals, metabolite diffusion within microbial communities can affect the composition and dynamics of the community in a manner that can be challenging to deconstruct. We used encapsulation of a synthetic microbial community within microdroplets to investigate the effects of spatial structure and metabolite diffusion on population dynamics and to examine the effects of cheating by one member of the community. The synthetic community was comprised of three strains: a 'Producer' that makes the diffusible quorum sensing molecule ( Abstract Figure:

Identifiers

PMID36711600
PMCPMC9882018
OpenAlexW4315621813

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.