ArticlebioRxiv : the preprint server for biology2023
Structure and DNA bridging activity of the essential Rec114â€"Mei4 trimer interface.
Kaixian Liu, Emily M Grasso, Stephen Pu, Shixin Liu, David Eliezer, Scott Keeney
Open access · greenAbstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 4 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
6 authors at 3 institutions in 1 country.
Kaixian LiuMolecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, USA.
Emily M GrassoDepartment of Biochemistry and Program in Structural Biology, Weill Cornell Medicine, New York, NY, USA.
Stephen PuMolecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, USA.
Shixin LiuLaboratory of Nanoscale Biophysics and Biochemistry, The Rockefeller University, New York, NY, USA.
David EliezerDepartment of Biochemistry and Program in Structural Biology, Weill Cornell Medicine, New York, NY, USA.
Scott KeeneyMolecular Biology Program, Memorial Sloan Kettering Cancer Center, New York, USA.
Memorial Sloan Kettering Cancer Center · USCornell University · USRockefeller University · US
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4MTR&D4: Integrated pipeline for data analysisP41GM118302 · NIGMS · NEW YORK STRUCTURAL BIOLOGY CENTER · PI PALMER, ARTHUR G · 2017 to 2021
$8.5MRM1 Center on Macromolecular Dynamics by NMR Spectroscopy at the New York Structural Biology Center (CoMD/NMR)- Equipment Supplement RequestRM1GM145397 · NIGMS · NEW YORK STRUCTURAL BIOLOGY CENTER · PI ARTHUR G PALMER · 2022 to 2026
$8.3MMechanism and regulation of meiotic recombinationR35GM118092 · NIGMS · SLOAN-KETTERING INST CAN RESEARCH · PI Scott Keeney · 2016 to 2026
$7.0MStructure and Function of Protein Disorder in Membrane Trafficking and OrganizationR35GM136686 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI ELIEZER, DAVID · 2020 to 2025
$4.5MProbing Symmetry Breaking in Epigenetic Inheritance: From Single Molecules to Systems BiologyDP2HG010510 · NHGRI · ROCKEFELLER UNIVERSITY · PI LIU, SHIXIN · 2018 to 2018
$2.5MStructural and functional principles underlying germline genome transmissionR01HD110120 · NICHD · SLOAN-KETTERING INST CAN RESEARCH · PI Scott Keeney, DINSHAW J PATEL · 2022 to 2026
$2.4MEXTRAMURAL RESEARCH FACILITIES CONSTRUCTIONC06RR015495 · NCRR · NEW YORK STRUCTURAL BIOLOGY CENTER · PI RIFKIND, RICHARD A · 2000 to 2000
$2.0MAcquisition of 700 MHz NMR SpectrometerS10OD018509 · OD · NEW YORK STRUCTURAL BIOLOGY CENTER · PI PALMER, ARTHUR G · 2015 to 2015
$1.1MAcquisition of a Cold Probe and Console for a 600MHz NMR spectrometerS10OD016320 · OD · WEILL MEDICAL COLL OF CORNELL UNIV · PI BRACKEN, WILLIAM C · 2013 to 2013
$600kUpgrade of 800 MHz SpectrometerS10OD016432 · OD · NEW YORK STRUCTURAL BIOLOGY CENTER · PI PALMER, ARTHUR G · 2014 to 2014
$600kUpgrade of the RF electronics console and probes for chemical biology.S10OD028556 · OD · WEILL MEDICAL COLL OF CORNELL UNIV · PI BRACKEN, WILLIAM C · 2020 to 2020
$600kNCI NIH HHS P30 CA008748NCRR NIH HHS C06 RR015495NHGRI NIH HHS DP2 HG010510NICHD NIH HHS R01 HD110120NIGMS NIH HHS P41 GM118302NIGMS NIH HHS R35 GM118092NIGMS NIH HHS R35 GM136686NIGMS NIH HHS RM1 GM145397NIH HHS S10 OD016320NIH HHS S10 OD016432NIH HHS S10 OD018509NIH HHS S10 OD028556
6 · The paper itselfAbstract
The DNA double-strand breaks (DSBs) that initiate meiotic recombination are formed by an evolutionarily conserved suite of factors that includes Rec114 and Mei4 (RM), which regulate DSB formation both spatially and temporally.
Identifiers
PMID36711595
PMCPMC9882322
OpenAlexW4317372339
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