Evidence map›Paper›PMID 36711562›Full record

ArticlebioRxiv : the preprint server for biology2023

CAS12e (CASX2) CLEAVAGE OF CCR5: IMPACT OF GUIDE RNA LENGTH AND PAM SEQUENCE ON CLEAVAGE ACTIVITY.

David A Armstrong, Taylor R Hudson, Christine A Hodge, Thomas H Hampton, Alexandra L Howell, Matthew S Hayden

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

David A ArmstrongResearch Service, V.A. Medical Center, White River Junction, VT, USA, 05001.ORCID 0000-0003-1748-2520
Taylor R HudsonResearch Service, V.A. Medical Center, White River Junction, VT, USA, 05001.
Christine A HodgeDepartment of Dermatology, Dartmouth Health, Lebanon, NH, USA, 03756.
Thomas H HamptonDepartment of Microbiology/Immunology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA, 03755.
Alexandra L HowellResearch Service, V.A. Medical Center, White River Junction, VT, USA, 05001.ORCID 0000-0002-2362-2596
Matthew S HaydenDepartment of Dermatology, Dartmouth Health, Lebanon, NH, USA, 03756.ORCID 0000-0003-1670-6430
Dartmouth College · USWhite River Junction VA Medical Center · US

Funding

Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Fred W Kolling IV · 1985 to 2026
$91.3M
Translational Research CoreP30DK117469 · NIDDK · DARTMOUTH COLLEGE · PI DEBORAH A HOGAN · 2018 to 2026
$13.9M
BLRD VA I01 BX005248NCI NIH HHS P30 CA023108NIDDK NIH HHS P30 DK117469
6 · The paper itself

Abstract

CRISPR/Cas is under development as a therapeutic tool for the cleavage, excision, and/or modification of genes in eukaryotic cells. While much effort has focused on CRISPR/Cas from

Identifiers

PMID36711562
PMCPMC9881857
OpenAlexW4313477846

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.