ArticlebioRxiv : the preprint server for biology2023
Bidirectional multiciliated cell extrusion is controlled by Notch driven basal extrusion and Piezo 1 driven apical extrusion.
Rosa Ventrella, Sun K Kim, Jennifer Sheridan, Aline Grata, Enzo Bresteau, Osama Hassan, Eve E Suva, Peter Walentek, Brian Mitchell
Open access · greenAbstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 3 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
9 authors at 3 institutions in 2 countries.
Rosa VentrellaNorthwestern University, Feinberg School of Medicine, Department of Cell and Developmental Biology.
Sun K KimNorthwestern University, Feinberg School of Medicine, Department of Cell and Developmental Biology.
Jennifer SheridanNorthwestern University, Feinberg School of Medicine, Department of Cell and Developmental Biology.
Aline GrataNorthwestern University, Feinberg School of Medicine, Department of Cell and Developmental Biology.
Enzo BresteauNorthwestern University, Feinberg School of Medicine, Department of Cell and Developmental Biology.
Osama HassanNorthwestern University, Feinberg School of Medicine, Department of Cell and Developmental Biology.
Eve E SuvaNorthwestern University, Feinberg School of Medicine, Department of Cell and Developmental Biology.
Peter WalentekUniversity of Freiburg, Renal Division, Internal Medicine IV, Medical Center and CIBSS Centre for Integrative Biological Signalling Studies.
Brian MitchellNorthwestern University, Feinberg School of Medicine, Department of Cell and Developmental Biology.
Midwestern University · USRobert H. Lurie Comprehensive Cancer Center of Northwestern UniversityUniversity of Freiburg · DE
Funding
Developmental Dynamics of Ciliated EpitheliaR01GM089970 · NIGMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MITCHELL, BRIAN JOSEPH · 2010 to 2022
$4.4MPost Graduate Program in Cutaneous BiologyT32AR060710 · NIAMS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Amy S Paller · 2012 to 2026
$2.4MDNA Nanotechnology platform for high-throughput cryo-EM studies of small proteinsF32GM119322 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AKSEL, TURAL · 2016 to 2017
$119kNIAMS NIH HHS T32 AR060710NIGMS NIH HHS F32 GM119322NIGMS NIH HHS R01 GM089970
6 · The paper itselfAbstract
Summay Statement: Cell extrusion typically occurs unidirectionally. We have identified a single population of multiciliated cells that extrudes bidirectionally: Notch-driven basal extrusion and Piezo 1-mediated apical extrusion.
Identifiers
PMID36711534
PMCPMC9882179
OpenAlexW4316035616
What OpenQuestion holds
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LicenceCC BY-NC
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