Evidence map›Paper›PMID 36711533›Full record

ArticleResearch square2023

Paneth cells as the origin of intestinal cancer in the context of inflammation.

Mathijs P Verhagen, Rosalie Joosten, Mark Schmitt, Andrea Sacchetti, Jiahn Choi, Niko Välimäki, Lauri A Aaltonen, Leonard H Augenlicht, Riccardo Fodde

Open access · greenAbstract readPreprint
In one paragraph

Article in Research square, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 4 countries.

Mathijs P VerhagenDepartment of Pathology, Erasmus University Medical Center, Rotterdam, The Netherlands.ORCID 0000-0003-3126-8379
Rosalie JoostenDepartment of Pathology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Mark SchmittDepartment of Pathology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Andrea SacchettiDepartment of Pathology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Jiahn ChoiDepartment of Cell Biology, Albert Einstein College of Medicine, New York, U.S.A.ORCID 0000-0001-7344-767X
Niko VälimäkiDepartment of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland.ORCID 0000-0001-9200-9560
Lauri A AaltonenDepartment of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland.ORCID 0000-0001-6839-4286
Leonard H AugenlichtDepartment of Cell Biology, Albert Einstein College of Medicine, New York, U.S.A.
Riccardo FoddeDepartment of Pathology, Erasmus University Medical Center, Rotterdam, The Netherlands.ORCID 0000-0001-9839-4324
Erasmus MC · NLAlbert Einstein College of Medicine · USUniversity of Helsinki · FIPhilipps University of Marburg · DE

Funding

Einstein's Nathan Shock Center of Excellence in Basic Biology of AgingP30AG038072 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI VIJG, JAN · 2010 to 2024
$10.8M
Training in Aging ResearchT32AG023475 · NIA · ALBERT EINSTEIN COL OF MED YESHIVA UNIV · PI NIR J BARZILAI, DEREK Major HUFFMAN · 2004 to 2026
$8.6M
Nutritionally Driven Sporadic Intestinal Tumors: Impact on Stem CellsR01CA229216 · NCI · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI AUGENLICHT, LEONARD H · 2018 to 2022
$2.4M
A Major Nutritional Effect on Intestinal Stem Cells and TumorsR01CA214625 · NCI · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI AUGENLICHT, LEONARD H · 2018 to 2022
$1.6M
NCI NIH HHS R01 CA214625NCI NIH HHS R01 CA229216NIA NIH HHS P30 AG038072NIA NIH HHS T32 AG023475
6 · The paper itself

Abstract

Paneth cells (PCs), responsible for the secretion of antimicrobial peptides in the small intestine and for niche support to

Identifiers

PMID36711533
PMCPMC9882659
OpenAlexW4317438946

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.