Evidence map›Paper›PMID 36711314›Full record

ReviewHeliyon2023

Automated analysis of mitochondrial dimensions in mesenchymal stem cells: Current methods and future perspectives.

Sabrina Summer, Agnes Kocsis, Eva Ingeborg Reihs, Mario Rothbauer, Kirill Lonhus, Dalibor Stys, Peter Ertl, Michael B Fischer

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Heliyon, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Sabrina SummerDepartment for Biomedical Research, Center of Experimental Medicine, Danube University Krems, Dr.-Karl-Dorrek-Straße 30, Krems an der Donau, Austria.
Agnes KocsisDepartment for Biomedical Research, Center of Experimental Medicine, Danube University Krems, Dr.-Karl-Dorrek-Straße 30, Krems an der Donau, Austria.
Eva Ingeborg ReihsKarl Chiari Lab for Orthopaedic Biology & Ludwig Boltzmann Institute for Arthritis and Rehabilitation, Department of Orthopedics and Trauma Surgery, Medical University of Vienna, Währinger Gürtel 18-20, Vienna, Austria.
Mario RothbauerKarl Chiari Lab for Orthopaedic Biology & Ludwig Boltzmann Institute for Arthritis and Rehabilitation, Department of Orthopedics and Trauma Surgery, Medical University of Vienna, Währinger Gürtel 18-20, Vienna, Austria.
Kirill LonhusInstitute of Complex Systems, Faculty of Fisheries and Protection of Waters, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, University of South Bohemia in České Budějovice, Zámek 136, 373 33 Nové Hrady, Czech Republic.
Dalibor StysInstitute of Complex Systems, Faculty of Fisheries and Protection of Waters, South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, University of South Bohemia in České Budějovice, Zámek 136, 373 33 Nové Hrady, Czech Republic.
Peter ErtlInstitute of Applied Synthetic Chemistry and Institute of Chemical Technologies and Analytics, Technical University Vienna, Faculty of Technical Chemistry, Getreidemarkt 9/163, Vienna, Austria.
Michael B FischerDepartment for Biomedical Research, Center of Experimental Medicine, Danube University Krems, Dr.-Karl-Dorrek-Straße 30, Krems an der Donau, Austria.
TU Wien · ATUniversität für Weiterbildung Krems · ATUniversity of South Bohemia in České Budějovice · CZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As centre of energy production and key regulators of metabolic and cellular signaling pathways, the integrity of mitochondria is essential for mesenchymal stem cell function in tissue regeneration. Alterations in the size, shape and structural organization of mitochondria are correlated with the physiological state of the cell and its environment and could be used as diagnostic biomarkers. Therefore, high-throughput experimental and computational techniques are crucial to ensure adequate correlations between mitochondrial function and disease phenotypes. The emerge of microfluidic technologies can address the shortcomings of traditional methods to determine mitochondrial dimensions for diagnostic and therapeutic use. This review discusses optical detection methods compatible with microfluidics to measure mitochondrial dynamics and their potential for clinical stem cell research targeting mitochondrial dysfunction.

Indexed as

Automated mitochondrial analysisMesenchymal stem cellsMicrofluidic systemsMitochondrial dynamicsMSC-Based therapies

Identifiers

PMID36711314
PMCPMC9873686
OpenAlexW4317380453

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.