Evidence map›Paper›PMID 36711215›Full record

ArticleACS applied nano materials2022

Nitrogen-Doped Carbon Nanotube Cups for Cancer Therapy.

Seth C Burkert, Xiaoyun He, Galina V Shurin, Yulia Nefedova, Valerian E Kagan, Michael R Shurin, Alexander Star

Abstract read
In one paragraph

Article in ACS applied nano materials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Seth C BurkertDepartment of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States.ORCID 0000-0002-5606-4826
Xiaoyun HeDepartment of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States.ORCID 0000-0001-7313-4585
Galina V ShurinDepartment of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15261, United States.
Yulia NefedovaThe Wistar Institute, Philadelphia, Pennsylvania 19104, United States.
Valerian E KaganDepartment of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States.ORCID 0000-0002-7245-1885
Michael R ShurinDepartment of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15261, United States.
Alexander StarDepartment of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States.ORCID 0000-0001-7863-5987

Funding

Tumor Microenvironment and MetastasisP30CA010815 · NCI · WISTAR INSTITUTE · PI Luis J Montaner · 1985 to 2026
$75.9M
Lipids and Myeloid Cell Function in CancerR01CA165065 · NCI · WISTAR INSTITUTE · PI KAGAN, VALERIAN E, MONTANER, LUIS J · 2012 to 2022
$3.8M
Therapeutic targeting MDSC-mediated immune suppression in cancerR01CA266342 · NCI · WISTAR INSTITUTE · PI Valerian E Kagan, Yulia Nefedova · 2022 to 2026
$3.5M
Investigations and Mitigation of Carbon Nanomaterial ToxicityR01ES019304 · NIEHS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI STAR, ALEXANDER · 2010 to 2014
$1.9M
NCI NIH HHS P30 CA010815NCI NIH HHS R01 CA165065NCI NIH HHS R01 CA266342NIEHS NIH HHS R01 ES019304
6 · The paper itself

Abstract

Carbon nanomaterials have attracted significant attention for a variety of biomedical applications including sensing and detection, photothermal therapy, and delivery of therapeutic cargo. The ease of chemical functionalization, tunable length scales and morphologies, and ability to undergo complete enzymatic degradation make carbon nanomaterials an ideal drug delivery system. Much work has been done to synthesize carbon nanomaterials ranging from carbon dots, graphene, and carbon nanotubes to carbon nanocapsules, specifically carbon nanohorns or nitrogen-doped carbon nanocups. Here, we analyze specific properties of nitrogen-doped carbon nanotube cups which have been designed and utilized as drug delivery systems with the focus on the loading of these nanocapsules with specific therapeutic cargo and the targeted delivery for cancer therapy. We also summarize our targeted synthesis of gold nanoparticles on the open edge of nitrogen-doped carbon nanotube cups to create loaded and sealed nanocarriers for the delivery of chemotherapeutic agents to myeloid regulatory cells responsible for the immunosuppressive properties of the tumor microenvironment and thus tumor immune escape.

Indexed as

cancer therapycarbon nanomaterialsdrug delivery systemmyeloid-derived suppressor cellsnitrogen-dopants

Identifiers

PMID36711215
PMCPMC9879341

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.