ArticleMacromolecules2023
Mechanics Underpinning Phase Separation of Hydrogels.
Article in Macromolecules, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Harnessing Phase Separation for the Development of High-Performance Hydrogels.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Mesenchymal stem cell-derived exosomes in myocardial infarction repair: therapeutic potential and scaffold-based delivery strategies.Frontiers in pharmacology · 2026Review
- Hydrogels in Simulated Microgravity: Thermodynamics at Play.Gels (Basel, Switzerland) · 2025Review
- Barnacle inspired strategy combined with solvent exchange for enhancing wet adhesion of hydrogels to promote seawater-immersed wound healing.Bioactive materials · 2024Article
- Engineered Vesicles and Hydrogel Technologies for Myocardial Regeneration.Gels (Basel, Switzerland) · 2023Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This paper reveals the underpinning role of mechanical constraints and dynamic loading in triggering volume phase transitions and phase separation of hydrogels. Using the Flory-Rehner free energy that does not predict phase separation of hydrogels under equilibrium free swelling, we show that mechanical constraints can lead to coexistence of multiple phases. We systematically obtain the states of equilibrium for hydrogels under various mechanical constraints and unravel how mechanical constraints change the convexity of the free energy and monotonicity of the stress-stretch curves, leading to phase coexistence. Using a phase-field model, we predict the pattern evolution of phase coexistence and show that many features cannot be captured by the homogeneous states of equilibrium due to large mismatch stretch between the coexisting phases. We further reveal that the system size, quenching rate, and loading rate can significantly influence the phase behavior, which provides insights for experimental studies related to morphological patterns of hydrogels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.