Evidence map›Paper›PMID 36711077›Full record

ArticleBrain hemorrhages2022

In vitro models of intracerebral hemorrhage.

Bilal Syed, Abhijit Nirwane, Yao Yao

Abstract read
In one paragraph

Article in Brain hemorrhages, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Review
  3. HumanBioactive materials · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. A double-edged effect of hypoxia on astrocyte-derived exosome releases.Experimental biology and medicine (Maywood, N.J.) · 2025
    Article
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Bilal SyedDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida, 33612, USA.
Abhijit NirwaneDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida, 33612, USA.
Yao YaoDepartment of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, Florida, 33612, USA.ORCID 0000-0001-8020-9696

Funding

Endothelial laminin in blood brain barrier regulationR01HL146574 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI YAO, YAO · 2019 to 2023
$1.9M
The roles of pericyte-derived laminin in neurovascular function and neurodegenerationRF1AG065345 · NIA · UNIVERSITY OF SOUTH FLORIDA · PI YAO, YAO · 2021 to 2021
$1.8M
Screening and identification of pericyte-specific and subpopulation-specific markersR21AG064422 · NIA · UNIVERSITY OF SOUTH FLORIDA · PI YAO, YAO · 2020 to 2021
$415k
Cell-specific changes of laminin expression in the CNS in Alzheimer’s diseaseR21AG073862 · NIA · UNIVERSITY OF SOUTH FLORIDA · PI YAO, YAO · 2021 to 2021
$411k
NHLBI NIH HHS R01 HL146574NIA NIH HHS R21 AG064422NIA NIH HHS R21 AG073862NIA NIH HHS RF1 AG065345
6 · The paper itself

Abstract

Intracerebral hemorrhage (ICH) is a severe clinical emergency caused by bleeding into brain parenchyma. Currently, there are no effective treatments to improve ICH outcomes. Developing new therapies for ICH relies on a thorough understanding of ICH pathophysiology and good in vitro models that enable mechanistic research. In this review, we summarized widely used in vitro ICH models and compared their advantages and disadvantages. Next, key questions that need to be answered in future research are discussed. We aim to provide a quick reference/summary of widely used in vitro ICH models and stimulate the development of new ICH models.

Indexed as

GlutamateHeminHemoglobinIntracerebral hemorrhageIn vitro modelOxidative stress

Identifiers

PMID36711077
PMCPMC9881459

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.