Evidence map›Paper›PMID 36710982›Full record

ArticleFrontiers in cellular and infection microbiology2022

Evaluation of bactericidal effects of silver hydrosol nanotherapeutics against

Alya Limayem, Mausam Mehta, Natalie Kondos, Divya Kaushal, Farhat Binte Azam, Sriram Chellappan, Nan Qin, Qingyu Zhou

Abstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alya LimayemDepartment of Biology, College of Arts & Sciences, University of North Florida, Jacksonville, FL, United States.
Mausam MehtaDepartment of Pharmaceutical Sciences, Graduate Program, Taneja College of Pharmacy, University of South Florida, Tampa, FL, United States.
Natalie KondosDepartment of Pharmaceutical Sciences, Graduate Program, Taneja College of Pharmacy, University of South Florida, Tampa, FL, United States.
Divya KaushalDepartment of Pharmaceutical Sciences, Graduate Program, Taneja College of Pharmacy, University of South Florida, Tampa, FL, United States.
Farhat Binte AzamDepartment of Computer Science & Engineering, College of Engineering, University of South Florida, Tampa, FL, United States.
Sriram ChellappanDepartment of Computer Science & Engineering, College of Engineering, University of South Florida, Tampa, FL, United States.
Nan QinDepartment of R&D and Analytical Services, Natural Immunogenics Corporation, Sarasota, FL, United States.
Qingyu ZhouDepartment of Pharmaceutical Sciences, Graduate Program, Taneja College of Pharmacy, University of South Florida, Tampa, FL, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Silver (Ag) nanoparticles (NPs) are well documented for their broad-spectrum bactericidal effects. This study aimed to test the effect of bioactive Ag-hydrosol NPs on drug-resistant Methods: The formation of Results: Treatment with Ag-hydrosol NPs at concentrations ranging from 12.4 mg/L to 123 mg/L resulted in 78.09% to 95.20% of biofilm reduction. No statistically significant difference in biofilm reduction was found among different batches of Ag-hydrosol NPs. Quantitative concentration-response relationship analysis indicated that Ag-hydrosol NPs exhibited a relative high anti-biofilm activity and low cytotoxicity with an average EC50 and TC50 values of 0.0333 and 6.55 mg/L, respectively, yielding an average therapeutic index value of 197. The AI-assisted TEM image analysis allowed automated detection of Discussion: Conclusively, the bioactive Ag-hydrosol NP is a promising nanotherapeutic agent against drug-resistant pathogens. The AI-assisted TEM image analysis was developed with the potential to assess its treatment effect.

Indexed as

Enterococcus faeciumSilverAnti-Bacterial AgentsArtificial IntelligenceBiofilmsHumansMicrobial Sensitivity TestsAnti-Bacterial AgentsSilverartificial intelligencebactericidal treatmentbioactive silver hydrosol nanoparticlescomputer visioncytotoxicityE. faeciummulti-drug resistance

Identifiers

PMID36710982
PMCPMC9875038

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.