Evidence map›Paper›PMID 36710929›Full record

ArticleFrontiers in molecular neuroscience2022

Pepperberg plot: Modeling flash response saturation in retinal rods of mouse.

Giovanni Caruso, Colin Klaus, Heidi E Hamm, Vsevolod V Gurevich, Paolo Bisegna, Daniele Andreucci, Emmanuele DiBenedetto, Clint L Makino

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in molecular neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 2 countries.

Giovanni CarusoItalian National Research Council, Istituto di Scienze del Patrimonio Culturale, Rome, Italy.
Colin KlausThe College of Public Health Division of Biostatistics and The Mathematical Biosciences Institute, The Ohio State University, Columbus, OH, United States.
Heidi E HammDepartment of Pharmacology, Vanderbilt University Medical Center, Nashville, TN, United States.
Vsevolod V GurevichDepartment of Pharmacology, Vanderbilt University Medical Center, Nashville, TN, United States.
Paolo BisegnaDepartment of Civil Engineering and Computer Science, University of Rome Tor Vergata, Rome, Italy.
Daniele AndreucciDepartment of Basic and Applied Sciences for Engineering, Sapienza University of Rome, Rome, Italy.
Emmanuele DiBenedettoDepartment of Mathematics, Vanderbilt University, Nashville, TN, United States.
Clint L MakinoDepartment of Physiology & Biophysics, Boston University Chobanian & Avedisian School of Medicine, Boston, MA, United States.
Vanderbilt University Medical Center · USBoston University · USNational Research Council · ITSapienza University of Rome · ITThe Ohio State University · USUniversity of Rome Tor Vergata · ITVanderbilt University · US

Funding

STRUCTURE/FUNCTION STUDIES OF VISUAL ARRESTINR01EY011500 · NEI · VANDERBILT UNIVERSITY · PI T M Iverson · 1997 to 2026
$12.3M
Rod outer segment structure: determinants and its effect on the photon responseR01EY031702 · NEI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MAKINO, CLINT L · 2020 to 2023
$2.2M
NEI NIH HHS R01 EY011500NEI NIH HHS R01 EY031702
6 · The paper itself

Abstract

Retinal rods evolved to be able to detect single photons. Despite their exquisite sensitivity, rods operate over many log units of light intensity. Several processes inside photoreceptor cells make this incredible light adaptation possible. Here, we added to our previously developed, fully space resolved biophysical model of rod phototransduction, some of the mechanisms that play significant roles in shaping the rod response under high illumination levels: the function of RGS9 in shutting off G protein transducin, and calcium dependences of the phosphorylation rates of activated rhodopsin, of the binding of cGMP to the light-regulated ion channel, and of two membrane guanylate cyclase activities. A well stirred version of this model captured the responses to bright, saturating flashes in WT and mutant mouse rods and was used to explain "Pepperberg plots," that graph the time during which the response is saturated against the natural logarithm of flash strength for bright flashes. At the lower end of the range, saturation time increases linearly with the natural logarithm of flash strength. The slope of the relation (τ

Indexed as

CNG channelcyclic GMPG proteinGRKmembrane guanylate cyclasePDERGS9visual transduction

Identifiers

PMID36710929
PMCPMC9880052
OpenAlexW4315784107

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.