ArticleNucleic acids research1987
A long polypyrimidine/polypurine tract induces an altered DNA conformation on the 3' coding region of the adjacent myosin heavy chain gene.
Article in Nucleic acids research, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 32 citations in OpenAlex.
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- Single-molecule analysis of i-motif within self-assembled DNA duplexes and nanocircles.Nucleic acids research · 2019Article
- Selective repression of RET proto-oncogene in medullary thyroid carcinoma by a natural alkaloid berberine.BMC cancer · 2015Article
- Article
- Possible regulatory roles of promoter g-quadruplexes in cardiac function-related genes - human TnIc as a model.PloS one · 2013Article
- Evidence of the formation of G-quadruplex structures in the promoter region of the human vascular endothelial growth factor gene.Nucleic acids research · 2011Article
- In vitro footprinting of promoter regions within supercoiled plasmid DNA.Methods in molecular biology (Clifton, N.J.) · 2010Article
- The importance of negative superhelicity in inducing the formation of G-quadruplex and i-motif structures in the c-Myc promoter: implications for drug targeting and control of gene expression.Journal of medicinal chemistry · 2009Article
- The GAA triplet-repeat expansion in Friedreich ataxia interferes with transcription and may be associated with an unusual DNA structure.American journal of human genetics · 1998Article
- De novo generation of simple sequence during gene amplification.Nucleic acids research · 1996Article
- Zuotin, a putative Z-DNA binding protein in Saccharomyces cerevisiae.The EMBO journal · 1992Article
- S1 nuclease hypersensitive sites in an oligopurine/oligopyrimidine DNA from the t(10;14) breakpoint cluster region.Nucleic acids research · 1992Article
- Human leukocyte antigen F (HLA-F). An expressed HLA gene composed of a class I coding sequence linked to a novel transcribed repetitive element.The Journal of experimental medicine · 1990Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A long (147 base pairs), natural A.T rich polypyrimidine/polypurine tract has been found 55 base pairs downstream of a chicken embryonic myosin heavy chain (MHC) gene. Analysis at the nucleotide level of nicks induced by S1 and Neurospora crassa nucleases indicate that this long interrupted polypyrimidine/polypurine tract exists in an alternate DNA structure in vitro at pH 4.5 and pH 7.5 in both supercoiled and linear plasmid DNA. The polypyrimidine/polypurine tract induces this alternate structure upon at least 200 base pairs of its 5' flanking DNA, and thus extends into the 3' coding and non-coding regions of the neighboring MHC gene. The different nicking patterns induced by the nucleases S1 and N. crassa on each strand of this alternate structure suggests that the polypyrimidine/polypurine tract may form heteronomous DNA. When this long polypyrimidine/polypurine tract is present in a supercoiled plasmid at low pH, a new and as yet undefined S1 hypersensitive DNA alteration was detected near the center of this tract.
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