Evidence map›Paper›PMID 36710491›Full record

ArticleMolecular therapy : the journal of the American Society of Gene Therapy2023

Long-term reversal of chronic pain behavior in rodents through elevation of spinal agmatine.

Cristina D Peterson, Jonathan J Waataja, Kelley F Kitto, Samuel J Erb, Harsha Verma, Daniel J Schuster, Caroline C Churchill, Maureen S Riedl, Lalitha R Belur, Daniel A Wolf and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy : the journal of the American Society of Gene Therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
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  4. Review
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  7. Agmatine suppresses the imidazoline IInternational journal of immunopathology and pharmacology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Cristina D PetersonDepartment of Pharmaceutics, University of Minnesota, Minneapolis, Minneapolis, MN 55455, USA; Department of Neuroscience, University of Minnesota, Minneapolis, College of Pharmacy, 9-177 Weaver Densford Hall, 308 Harvard Street S.E., Minneapolis, MN 55455, USA; Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, Minneapolis, MN 55455, USA.
Jonathan J WaatajaDepartment of Neuroscience, University of Minnesota, Minneapolis, College of Pharmacy, 9-177 Weaver Densford Hall, 308 Harvard Street S.E., Minneapolis, MN 55455, USA.
Kelley F KittoDepartment of Neuroscience, University of Minnesota, Minneapolis, College of Pharmacy, 9-177 Weaver Densford Hall, 308 Harvard Street S.E., Minneapolis, MN 55455, USA.
Samuel J ErbDepartment of Pharmaceutics, University of Minnesota, Minneapolis, Minneapolis, MN 55455, USA.
Harsha VermaDepartment of Pharmaceutics, University of Minnesota, Minneapolis, Minneapolis, MN 55455, USA.
Daniel J SchusterDepartment of Neuroscience, University of Minnesota, Minneapolis, College of Pharmacy, 9-177 Weaver Densford Hall, 308 Harvard Street S.E., Minneapolis, MN 55455, USA.
Caroline C ChurchillDepartment of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, Minneapolis, MN 55455, USA.
Maureen S RiedlDepartment of Neuroscience, University of Minnesota, Minneapolis, College of Pharmacy, 9-177 Weaver Densford Hall, 308 Harvard Street S.E., Minneapolis, MN 55455, USA.
Lalitha R BelurDepartment of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minneapolis, MN 55455, USA.
Daniel A WolfDepartment of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minneapolis, MN 55455, USA.
R Scott McIvorDepartment of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minneapolis, MN 55455, USA.
Lucy VulchanovaDepartment of Neuroscience, University of Minnesota, Minneapolis, College of Pharmacy, 9-177 Weaver Densford Hall, 308 Harvard Street S.E., Minneapolis, MN 55455, USA.
George L WilcoxDepartment of Neuroscience, University of Minnesota, Minneapolis, College of Pharmacy, 9-177 Weaver Densford Hall, 308 Harvard Street S.E., Minneapolis, MN 55455, USA; Department of Pharmacology, University of Minnesota, Minneapolis, Minneapolis, MN 55455, USA; Department of Dermatology, University of Minnesota, Minneapolis, Minneapolis, MN 55455, USA.
Carolyn A FairbanksDepartment of Pharmaceutics, University of Minnesota, Minneapolis, Minneapolis, MN 55455, USA; Department of Neuroscience, University of Minnesota, Minneapolis, College of Pharmacy, 9-177 Weaver Densford Hall, 308 Harvard Street S.E., Minneapolis, MN 55455, USA; Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, Minneapolis, MN 55455, USA; Department of Pharmacology, University of Minnesota, Minneapolis, Minneapolis, MN 55455, USA. Electronic address: carfair@umn.edu.
University of Minnesota · US

Funding

Mechanisms of Opioid Receptor InteractionsR01DA015438 · NIDA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI WILCOX, GEORGE LATIMER · 2004 to 2014
$3.3M
Peripheral Mechanisms of Sensory Neuron PlasticityK01DA017236 · NIDA · UNIVERSITY OF MINNESOTA TWIN CITIES · PI VULCHANOVA, LYUDMILA H · 2004 to 2008
$643k
Gene Therapy for PainR21DA025164 · NIDA · UNIVERSITY OF MINNESOTA · PI FAIRBANKS, CAROLYN A · 2008 to 2009
$302k
Gene Therapy in Chronic PainF31NS063634 · NINDS · UNIVERSITY OF MINNESOTA · PI SCHUSTER, DANIEL J. · 2009 to 2011
$95k
NIDA NIH HHS K01 DA017236NIDA NIH HHS R01 DA015438NIDA NIH HHS R21 DA025164NINDS NIH HHS F31 NS063634
6 · The paper itself

Abstract

Chronic pain remains a significant burden worldwide, and treatments are often limited by safety or efficacy. The decarboxylated form of L-arginine, agmatine, antagonizes N-methyl-d-aspartate receptors, inhibits nitric oxide synthase, and reverses behavioral neuroplasticity. We hypothesized that expressing the proposed synthetic enzyme for agmatine in the sensory pathway could reduce chronic pain without motor deficits. Intrathecal delivery of an adeno-associated viral (AAV) vector carrying the gene for arginine decarboxylase (ADC) prevented the development of chronic neuropathic pain as induced by spared nerve injury in mice and rats and persistently reversed established hypersensitivity 266 days post-injury. Spinal long-term potentiation was inhibited by both exogenous agmatine and AAV-human ADC (hADC) vector pre-treatment but was enhanced in rats treated with anti-agmatine immunoneutralizing antibodies. These data suggest that endogenous agmatine modulates the neuroplasticity associated with chronic pain. Development of approaches to access this inhibitory control of neuroplasticity associated with chronic pain may yield important non-opioid pain-relieving options.

Indexed as

AgmatineChronic PainAnimalsHumansMiceRatsReceptors, N-Methyl-D-AspartateRodentiaAgmatineReceptors, N-Methyl-D-AspartateAAV gene therapyagmatineanalgesiaarginine decarboxylasechronic painneuropathic painneuroplasticityNMDA receptorspinal electrophysiologyspinal long-term potentiation

Identifiers

PMID36710491
PMCPMC10124077
OpenAlexW4318465479

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.