ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2023
Membrane Targeted Azobenzene Drives Optical Modulation of Bacterial Membrane Potential.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- Light-controlled inhibition of Gram-positive bacteria by photoswitchable amphiphilic lipids (PALs).RSC medicinal chemistry · 2026Article
- Optimization of an improved chemically defined medium for high-efficiency expression of glucokinase in Escherichia coli.Microbial cell factories · 2026Article
- Illuminating the dark majority: photobiology of nonphotosynthetic bacteria.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2025Review
- Integrated Phenotypic and Transcriptomic Analyses Unveil the Antibacterial Mechanism of Punicalagin Against Methicillin-ResistantFoods (Basel, Switzerland) · 2025Article
- Designing Light-Sensitive Organic Semiconductors with Azobenzenes for Photoelectrochemical Transistors as Neuromorphic Platforms.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Covalent carbon nanodot-azobenzene hybrid photoswitches: the impact ofJournal of materials chemistry. C · 2025Article
- Physical communication pathways in bacteria: an extra layer to quorum sensing.Biophysical reviews · 2025Review
- Group IB Metal-Based Nanomaterials for Antibacterial Applications.Small science · 2025Review
- Photocontrol of bacterial membrane potential regulates antibiotic persistence inEuropean physical journal plus · 2025Article
- Membrane-targeted push-pull azobenzenes for the optical modulation of membrane potential.Light, science & applications · 2025Article
- Role of stretch-activated channels in light-generated action potentials mediated by an intramembrane molecular photoswitch.Journal of translational medicine · 2024Article
- Materials-driven strategies in bacterial engineering.MRS communications · 2024Review
- Modulation of Mechanosensitive Potassium Channels by a Membrane-targeted Nongenetic Photoswitch.The journal of physical chemistry. B · 2023Article
- Informing the Cannabis Conjecture: From Life's Beginnings to Mitochondria, Membranes and the Electrome-A Review.International journal of molecular sciences · 2023Review
- Light-Based Anti-Biofilm and Antibacterial Strategies.Pharmaceutics · 2023Review
- A membrane intercalating metal-free conjugated organic photosensitizer for bacterial photodynamic inactivation.Chemical science · 2023Article
- Article
- Membrane Targeted Azobenzene Drives Optical Modulation of Bacterial Membrane Potential.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Bacteria associated with glioma: a next wave in cancer treatment.Frontiers in cellular and infection microbiology · 2023Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
Recent studies have shown that bacterial membrane potential is dynamic and plays signaling roles. Yet, little is still known about the mechanisms of membrane potential dynamics regulation-owing to a scarcity of appropriate research tools. Optical modulation of bacterial membrane potential could fill this gap and provide a new approach for studying and controlling bacterial physiology and electrical signaling. Here, the authors show that a membrane-targeted azobenzene (Ziapin2) can be used to photo-modulate the membrane potential in cells of the Gram-positive bacterium Bacillus subtilis. It is found that upon exposure to blue-green light (λ = 470 nm), isomerization of Ziapin2 in the bacteria membrane induces hyperpolarization of the potential. To investigate the origin of this phenomenon, ion-channel-deletion strains and ion channel blockers are examined. The authors found that in presence of the chloride channel blocker idanyloxyacetic acid-94 (IAA-94) or in absence of KtrAB potassium transporter, the hyperpolarization response is attenuated. These results reveal that the Ziapin2 isomerization can induce ion channel opening in the bacterial membrane and suggest that Ziapin2 can be used for studying and controlling bacterial electrical signaling. This new optical tool could contribute to better understand various microbial phenomena, such as biofilm electric signaling and antimicrobial resistance.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.